Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors

Launched by UNIVERSIDAD AUTONOMA DE BAJA CALIFORNIA · Mar 4, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how insomnia, a common sleep disorder, affects overall health, including heart and metabolic conditions, and the stability of our DNA. Researchers want to understand how insomnia impacts people differently, especially among groups like athletes, older adults, university students, and those with metabolic syndrome. They will look at factors such as body composition, fitness levels, and lifestyle habits to see how they relate to insomnia and its effects on health.

If you are between 18 and 75 years old and generally healthy, you might be eligible to join the study. Participants will be asked to meet certain health criteria, like having a healthy waist size and blood pressure. The study does not involve any long-term dietary or exercise changes, and those who are selected will help researchers learn more about the connections between sleep issues and health. Your participation could contribute to developing better ways to manage insomnia and improve health outcomes for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Each population group will meet the following inclusion criteria:
• • Healthy Individuals (18-35 years old, men and women)
• • Waist circumference: \<90 cm (men), \<80 cm (women)
• • Fasting glucose: 70-110 mg/dL
• • Blood pressure: \<120/80 mmHg
• • Triglycerides: \<150 mg/dL
• • HDL-C: \>40 mg/dL (men), \>50 mg/dL (women)
• • Physical activity level: 600-1500 MET-min/week
• • Athletes (18-35 years old, men and women)
• • \*Engaged in structured sports training with a physical activity level \>1500 MET-min/week
• • Older Adults (65-75 years old, men and women)
• • \*Free of cognitive or mental health disorders. No specific cardiometabolic or body composition criteria due to the study's exploratory nature.
• • University Students (18-35 years old, men and women)
• • \*No specific cardiometabolic or body composition criteria due to the study's exploratory nature.
• • Individuals with Metabolic Syndrome (18-35 years old, men and women)
• • Waist circumference: \>90 cm (men), \>80 cm (women)
• • Fasting glucose: \>110 mg/dL
• • Blood pressure: \>130/80 mmHg
• • Triglycerides: \>150 mg/dL
• • HDL-C: \<40 mg/dL (men), \<50 mg/dL (women)
• • Physical activity level: \<600 MET-min/week
• Exclusion Criteria:
• • Individuals with respiratory diseases or musculoskeletal injuries that prevent exercise, as determined by a clinical history review, a physical activity readiness questionnaire (PART-Q+), and pulmonary function tests (spirometry).
• • Individuals with rotating or night-shift work schedules (e.g., emergency personnel, security guards), as circadian rhythm disruptions significantly impact sleep quality
• • Women diagnosed with polycystic ovary syndrome (PCOS) or showing high testosterone levels with a history of oligomenorrhea, as these conditions may influence metabolic and hormonal markers. However, women with menstrual irregularities related to premenstrual syndrome (PMS) or dysmenorrhea will not be excluded, given the established link between sleep disorders and menstrual cycle variations
• • This study does not involve chronic dietary or exercise interventions, nor does it require long-term participant follow-up, so no additional exclusion criteria apply