Brain Training for Substance Use Disorders

Launched by NEUROTYPE INC. · Mar 5, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Brain Training for Substance Use Disorders," is examining a new approach to help people struggling with opioid use disorder (OUD). Participants will play specially designed games that focus on improving their attention towards everyday activities that don't involve drugs. The games are paired with a system that monitors brain activity through a device called an EEG, which helps adjust the game's difficulty based on how the player performs. This study aims to see if this type of brain training can support recovery from opioid addiction.

To participate, individuals must be between the ages of 18 and 65, currently receiving treatment for opioid use disorder, and able to understand and provide consent. Control participants—those who do not have OUD but match the age and gender of participants with OUD—are also welcome. All participants should be able to read at least at a sixth-grade level and provide their contact information for follow-ups. It’s important to note that pregnant individuals, those with certain serious neurological issues, and those currently using opioids or other drugs are not eligible. Participants can expect to engage in interactive gameplay while providing valuable data that could help improve treatment methods for opioid addiction.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• OUD patient participants:
• • Admitted into chemical treatment with opioid use being a reason for treatment;
• • DSM-IV-TR diagnosis of OUD;
• • Ability to provide informed consent;
• • A minimum of a 6th grade reading level; and
• • Able and willing to provide own contact information for follow-up visit(s).
• Control participants:
• • Age- and gender-matched to an OUD patient participant in the study;
• • Ability to provide informed consent;
• • A minimum of a 6th grade reading level;
• • Able and willing to provide own contact information for follow-up visit(s).
• Exclusion Criteria:
• OUD patient participants:
• • Refusal or inability to consent;
• • Pregnant;
• • History of serious neurological illness (e.g., Chronic seizure disorder, Wernicke-Korsakoff Syndrome, Epilepsy, Any history of seizures not caused by withdrawal from substances, Other \[please specify\]);
• • Inability to see text and photos clearly on the computer display; and
• • Unwillingness to change hairstyle (e.g., braids, pony tails, dreadlocks) or remove wig to accommodate application of the EEG headset, if necessary.
• Control participants:
• • Refusal or inability to consent;
• • Pregnant;
• • History of serious neurological illness (e.g., Chronic seizure disorder, Wernicke-Korsakoff Syndrome, Epilepsy, Any history of seizures, Other \[please specify\]);
• • Inability to see text and photos clearly on the computer display;
• • Current or previous problems using opioids, other prescription (prescribed or not prescribed) or illicit drugs;
• • Regular nicotine user (e.g., cigarette smoker, e-cig user) within the past 12 months; and
• • Unwillingness to change hairstyle (e.g., braids, pony tails, dreadlocks) or remove wig to accommodate application of the EEG headset, if necessary.