IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding

Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Mar 10, 2025

Keywords

ClinConnect Summary

The clinical trial titled "IGHID 12334 - After the Flood" is studying how to prevent malaria infections in villages that experience severe flooding. Researchers will test different strategies to see which one works best at reducing the number of malaria cases. All participating villages will receive new bed nets to help protect against mosquito bites. Some villages will also get a monthly medication called Dihydroartemisinin-piperaquine (DP), which is a drug used to treat malaria, while others will receive a treatment to stop mosquitoes from breeding in water around their homes. The study will last for 12 months, and researchers will monitor the villages for malaria infections and mosquito activity.

To participate in this trial, you need to be a permanent resident of a flood-prone village in the Kasese District and willing to follow the study procedures. This means you should be able to commit to the study for a year and provide consent (or have a parent or guardian do so if you are under 18). Participants can expect to receive support with malaria prevention and contribute to important research that could help communities affected by flooding in the future. This study is particularly important as flooding and its impact on health are becoming more common.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Permanent resident of flood-prone village in Kasese District with no plans to change residency in subsequent 12 months
• • Able and willing to comply with all study procedures and be available for the duration of the study
• • Able and willing to consent to study procedures as documented on informed consent form (ICF). For children (age \<18 years), parent or guardian must provide consent. Children age ≥8 to 17 years will also be asked to provide written assent.
• Exclusion Criteria:
• • Temporary or part-time residence in study village
• • Plans to move in the next 12 months
• • Unable or unwilling to provide consent.
• • Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.