Standard Versus Oesophago-gastric Junction Complex Myotomy for Treatment naïve Type 2 Achalasia Patients

Launched by ASIAN INSTITUTE OF GASTROENTEROLOGY, INDIA · Mar 6, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring two different surgical methods to treat patients with Type 2 Achalasia, a condition that affects the esophagus and makes it hard for food to pass into the stomach. Participants will be randomly assigned to one of two groups: one will undergo a standard myotomy, while the other will receive a specialized procedure called esophagogastric junction complex myotomy. This means that half of the participants will have one type of surgery and half will have the other, and neither the patients nor the doctors assessing their progress will know which surgery is being performed to ensure fairness in the results.

To be eligible for this trial, participants must be adults over 18 years old and diagnosed with Type 2 Achalasia based on specific tests. Unfortunately, those with other types of Achalasia or previous treatments for this condition will not be included. If you join the trial, you can expect to receive either of the two surgical options and will be followed up on for three months to see how well the treatment worked. The trial is currently looking for participants and aims to better understand the best surgical approach for this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult \>18 years
• • Diagnosis of Type 2 Achalasia cardia based on High resolution manometry.
• Exclusion Criteria:
• • Patients with Type 1 \& 3 ACHALASIA CARDIA
• • Patients with previous endoscopic or surgical treatment for achalasia
• • Patients with standard exclusion criteria for POEM procedure such as contraindication to general anesthesia, coagulopathy (international normalized ratio \> 1.5, platelet count \< 50 000/μL), portal hypertension, pregnancy, breast feeding women, and diffuse scarring in the esophagus due to previous surgery or radiation.