How a Plant-Based Diet Affects Blood Pressure and Gut Health in Kidney Transplant Patient

Launched by MAHIDOL UNIVERSITY · Mar 6, 2025

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ClinConnect Summary

Kidney transplantation is the best therapeutic option for patients with advanced CKD and ESKD. It significantly improves quality of life and survival. However, kidney transplant recipients remain facing higher mortality compared to the general population. Similar to the non-transplant population, cardiovascular disease (CVD) is the most common cause of mortality in kidney transplant recipients and hypertension is one of the most common risk factors for CVD. While a plant-based diet is associated with improved blood pressure control, there is a lack of evidence of the benefit of a plant-base...

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Eligibility criteria

• Inclusion Criteria:
• • Receive kidney transplantation after 6 months and before 18 months with a stable kidney allograft function defined by ≤ 25% change in an estimated glomerular filtration rate (eGFR) from the baseline eGFR at 3-month post-transplant for 2 consecutive values closest to the date of randomization. The most recent eGFR before randomization ≥ 30 ml/min/1.73 m2.
• • An average SBP ≥ 130 and ≤ 160 mmHg at the time of randomization.
• • No change in type and dose of antihypertensive medications ≥ 1 month before randomization or no initiation of new antihypertensive medication ≥ 1 month before randomization
• • Anticipated to have no change in type and dose of antihypertensive medications during the 12-week study period.
• • Can come to follow up per study protocol.
• Exclusion Criteria:
• • Combined solid organ transplantation
• • Serum sodium \< 135 mmol/L before randomization
• • Serum potassium \> 5.5 mmol/L before randomization
• • History of acute kidney allograft rejection of the current kidney allograft