Acellular Collagen Matrix As a Tool to Obtain Wound Closure Following a Guided Bone Regeneration Procedure

Launched by OHIO STATE UNIVERSITY · Mar 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called an acellular collagen matrix, which is used during a procedure known as guided bone regeneration (GBR). GBR is performed to help rebuild bone in the jaw, especially when someone has lost a tooth and needs a dental implant. During the GBR procedure, a special barrier membrane is placed over bone grafting material to protect it. Sometimes, this membrane isn't completely covered by the gum tissue, leaving it exposed. In those cases, researchers want to see if placing an acellular collagen matrix over the membrane can help the healing process.

To participate in this study, patients need to have missing teeth that they plan to replace with implants and must require GBR to ensure there is enough bone for the implant. Participants will receive the GBR procedure as part of their regular dental care, and if their membrane is exposed, they may receive the acellular matrix. Throughout the study, additional measurements will be taken, and participants will be asked about their experiences. It's important to know that the study won't change the care patients receive; the decision to use the acellular matrix will be made by their dental surgeon based on what they think is best for each individual.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Have a missing tooth or teeth which are planned to be replaced with an implant
• • Need for guided bone regeneration procedure to increase the bone available for implant placement
• • Systemically healthy with no contraindications for bone grafting and/or implant surgery
• • No chronic sinus problems
• • Non-smoker
• • No need for removable temporary restorations during wound healing.
• Exclusion Criteria:
• • Patients that have sufficient bone volume to perform implant placement through conventional drilling protocol without any pre-implant GBR procedure
• • Indications for pre-implant/pre-GBR soft tissue grafting procedure to increase existing soft tissue contours
• • The need to wear a removable temporary restoration during healing