Effect of Melatonin on Postoperative Pain After Simple Nephrectomy

Launched by CAIRO UNIVERSITY · Mar 7, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of melatonin on pain management after a surgical procedure called simple nephrectomy, which involves removing a kidney. The researchers want to see if giving melatonin can help reduce pain, how much pain medication (like morphine) is needed in the first 24 hours after surgery, and how satisfied patients feel about their pain control. They will also look at other factors like anxiety levels and any side effects that might occur.

To participate, you need to be between 18 and 65 years old and be scheduled for a simple nephrectomy. Some people may not be eligible, including those with allergies to melatonin or certain health conditions, such as heart problems or mental impairments. If you join the trial, you can expect to receive melatonin and be monitored for your pain levels and overall experience after surgery. This study is currently recruiting participants, so if you are interested, it’s a good idea to discuss it with your healthcare provider for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age from 18 to 65 years.
• • Both sexes.
• • (ASA) physical status I, II.
• • Patients undergoing simple nephrectomy.
• Exclusion Criteria:
• • Patient refusal.
• • Patients with a history of allergic reactions to melatonin.
• • Patients receiving drugs with known analgesic and sedative properties.
• • Body Mass Index (BMI) over 30 kg/m2.
• • Drug or alcohol abuse.
• • History of cardiovascular disease.
• • Renal Failure.
• • Mental impairment.
• • Renal impairment.