Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults

Launched by PURDUE UNIVERSITY · Mar 6, 2025

Keywords

ClinConnect Summary

Background:

This randomized, crossover clinical trial aims to evaluate the effects of two types of dietary fibers (soluble arabinoxylan and rice bran) compared to a control (maltodextrin) on gut microbiota and intestinal health in healthy adults aged 18-45. Insoluble rice bran, a fiber derived as a cereal by-product, may provide special support of a group of beneficial gut bacteria, and may compare well to its soluble arabinoxylan counterpart. This study will provide insights into whether rice bran, as a fiber source, offers additional benefits compared to the extracted soluble form alone....

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men or women.
• • Aged between 18-45 years.
• • Body mass index between 18.5 and 25 kg/m².
• • Able to read/speak English.
• Exclusion Criteria:
• • Gastrointestinal disorders (inflammatory bowel disease, irritable bowel syndrome, gluten sensitivity/intolerance, etc.).
• • Those who took antibiotics 3 months before the study.
• • Individuals taking regular medication or supplements that might affect the gut microbiota.
• • Individuals undertaking weight-loss diets.
• • Unstable body weight (±3 kg in the past 3 months), and individuals below 110 lb.
• • Heavy drinkers (for men, consuming more than 4 drinks on any day or more than 14 drinks per week; for women, consuming more than 3 drinks on any day or more than 7 drinks per week).
• • Smokers (those who have smoked 100 cigarettes in their lifetime and who currently smoke cigarettes, even every day or occasionally).
• • Breastfeeding or pregnant women.