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Search / Trial NCT06873204

Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults

Launched by PURDUE UNIVERSITY · Mar 6, 2025

Trial Information

Current as of April 23, 2025

Not yet recruiting

Keywords

Gut Microbiota Dietary Fiber Soluble Arabinoxylan Rice Bran Fiber Intestinal Health Butyrate Producing Bacteria Clostridium Cluster I Va Short Chain Fatty Acids

ClinConnect Summary

Background:

This randomized, crossover clinical trial aims to evaluate the effects of two types of dietary fibers (soluble arabinoxylan and rice bran) compared to a control (maltodextrin) on gut microbiota and intestinal health in healthy adults aged 18-45. Insoluble rice bran, a fiber derived as a cereal by-product, may provide special support of a group of beneficial gut bacteria, and may compare well to its soluble arabinoxylan counterpart. This study will provide insights into whether rice bran, as a fiber source, offers additional benefits compared to the extracted soluble form alone....

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Men or women.
  • Aged between 18-45 years.
  • Body mass index between 18.5 and 25 kg/m².
  • Able to read/speak English.
  • Exclusion Criteria:
  • Gastrointestinal disorders (inflammatory bowel disease, irritable bowel syndrome, gluten sensitivity/intolerance, etc.).
  • Those who took antibiotics 3 months before the study.
  • Individuals taking regular medication or supplements that might affect the gut microbiota.
  • Individuals undertaking weight-loss diets.
  • Unstable body weight (±3 kg in the past 3 months), and individuals below 110 lb.
  • Heavy drinkers (for men, consuming more than 4 drinks on any day or more than 14 drinks per week; for women, consuming more than 3 drinks on any day or more than 7 drinks per week).
  • Smokers (those who have smoked 100 cigarettes in their lifetime and who currently smoke cigarettes, even every day or occasionally).
  • Breastfeeding or pregnant women.

About Purdue University

Purdue University is a renowned research institution dedicated to advancing knowledge and innovation across various fields, including health and medicine. As a clinical trial sponsor, Purdue leverages its extensive academic resources and multidisciplinary expertise to conduct rigorous research aimed at improving patient outcomes and contributing to the scientific community. With a commitment to ethical standards and regulatory compliance, Purdue University collaborates with healthcare professionals and industry partners to translate research findings into practical applications, ultimately enhancing the quality of care and addressing critical health challenges.

Locations

West Lafayette, Indiana, United States

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported