Oropharyngeal Vs Intravenous Lidocaine Effects on Optic Nerve Sheath Diameter After Intubation

Launched by ANKARA CITY HOSPITAL BILKENT · Mar 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different methods of using lidocaine, a numbing medication, affect the optic nerve sheath diameter (ONSD) after a procedure called endotracheal intubation, which is commonly done during surgeries to help patients breathe. The trial will compare two ways of giving lidocaine: one method uses a topical spray in the mouth (oropharyngeal) and the other uses an intravenous (IV) injection. Researchers will measure the ONSD using ultrasound before intubation and at intervals afterward to see how each method affects the optic nerve.

To participate in this trial, you need to be between 18 and 65 years old, have a body mass index (BMI) between 18 and 30, and not have any serious health conditions that could make intubation difficult. You also should not have a history of eye problems or conditions that increase pressure in the brain. If you qualify and choose to participate, you can expect to have some ultrasound measurements taken before and after the intubation. This research aims to help improve patient care during surgeries by understanding the best ways to use lidocaine for numbing.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ASA class I or II
• • Age 18-65 years
• • BMI 18-30
• • No history or expected difficult intubation
• • No glaucoma or ocular pathology
• • No intracranial pressure increase
• Exclusion Criteria:
• • ASA class III and above
• • Obesity (BMI \> 30)
• • Difficult intubation history or risk
• • Glaucoma or other ophthalmic pathology
• • History of intracranial pressure increase or prior ophthalmic/intracranial surgery
• • Preoperative sedation
• • Active malignancy or ongoing radiotherapy/chemotherapy