A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels

Launched by ISLAMIC AZAD UNIVERSITY, SANANDAJ · Mar 12, 2025

Keywords

ClinConnect Summary

This study tests whether two mouthwashes—chlorhexidine (CHX) and green tea—can help people with gingivitis, a common gum inflammation. In about 84 adults aged 18–40 with at least 20 natural teeth, researchers will collect gum health measures and a saliva sample to look at immune cells (neutrophils) and overall antioxidant levels, plus a simple plaque check, before and after about three months. Participants are randomly assigned to CHX mouthwash or a Green Tea mouthwash and neither participants nor researchers know which one is being used (double-blind). People with certain health conditions, recent antibiotic or periodontal treatment, tobacco use, pregnancy, or other factors are not eligible.

All participants undergo a dental cleaning (scaling and root planing) and receive oral hygiene guidance. Then they use the assigned mouthwash twice daily for about two months. Researchers will reassess gum health, collect a second saliva sample, and compare the results between the two groups. The trial is currently enrolling, with completion expected around early to mid-2025, and results are not yet available.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • a minimum of 20 natural teeth; a mean plaque index (PI) of at least 1.5, (10); a mean gingival index (GI) of at least 1.0 (Patients with a gingival index score of ≥1 at more than 60% of sites
• Exclusion Criteria:
• • with systemic diseases, those who had undergone antibiotic therapy in the past three months, and anyone who had received periodontal treatment within the last six months. Participants diagnosed with aggressive periodontitis, individuals with known allergies to statin medications, and those currently undergoing statin treatment or using medications that may affect periodontal health were also not eligible. Furthermore, individuals who are immunocompromised, those who use tobacco products, and lactating or pregnant women were excluded from participation.