Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles

Launched by DUNAMENTI REK ISTENHEGYI IVF CENTER · Mar 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether women undergoing a modified natural cycle frozen embryo transfer (mNC-FET) need extra support from progesterone after their embryo transfer. Progesterone is a hormone that helps prepare the uterus for pregnancy, but there is some debate about whether it is necessary in these specific cases. The trial aims to find out if giving progesterone makes a difference in the success of the embryo transfer.

To participate, women must be between 18 and 40 years old, have at least one high-quality frozen embryo, and plan to transfer just one embryo. They should also have a regular menstrual cycle and a healthy body mass index (BMI). Participants will be randomly assigned to one of three groups: one group will not receive progesterone support, the second group will get vaginal progesterone after the embryo transfer, and the third group will receive both progesterone and a hormone injection. Throughout the study, researchers will compare the outcomes to see if the different treatments have any impact on the chances of a successful pregnancy. This trial is not yet recruiting, but it represents an important step in understanding the best care for women undergoing these procedures.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age 18-40 years at the time of vitrification
• • At least one good quality blastocyst frozen
• • Planned 1 blastocyst transfer
• • \<3 failed previous ETs
• • Cycle length between 21-35 days
• • Body mass index (BMI): 18-35 kg/m2
• • Intact uterine cavity based on hysteroscopy, hysteron-salpingogram, salina sonohysterogram
• • Consent to participate
• Exclusion Criteria:
• • Age \<18 of over 40 at the time of vitrification
• • BMI: \<18 kg/m2 or \>35 kg/m2
• • Planned transfer of more than 1 embryo
• • Irregular cycles (\<21 or \>35 days)
• • Use of a protocol other than the modified natural cycle frozen embryo transfer
• • Lack of good morphology blastocysts
• • No evidence for spontaneous follicle development (no dominant (\>17 mm) follicle by day 20 of cycle)
• • Patient with a history of recurrent miscarriages
• • Presence of a hydrosalpinx
• • Irregular uterine cavity
• • Positive test for HIV, hepatitis B or C
• • Lack of consent