Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles

Launched by DUNAMENTI REK ISTENHEGYI IVF CENTER · Mar 11, 2025

Keywords

ClinConnect Summary

Aim: The aim of this RCT is to assess whether the use of luteal support improves the outcome of modified natural cycle frozen embryo transfer (FET) treatments.

Background: Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product. In the follicular phase the increasing amount of estradiol secreted by the growing follicle builds up the endometrium, while in the luteal phase progesterone, the main product of the corpus luteum, prepares the endometrium for implantation...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age 18-40 years at the time of vitrification
• • At least one good quality blastocyst frozen
• • Planned 1 blastocyst transfer
• • \<3 failed previous ETs
• • Cycle length between 21-35 days
• • Body mass index (BMI): 18-35 kg/m2
• • Intact uterine cavity based on hysteroscopy, hysteron-salpingogram, salina sonohysterogram
• • Consent to participate
• Exclusion Criteria:
• • Age \<18 of over 40 at the time of vitrification
• • BMI: \<18 kg/m2 or \>35 kg/m2
• • Planned transfer of more than 1 embryo
• • Irregular cycles (\<21 or \>35 days)
• • Use of a protocol other than the modified natural cycle frozen embryo transfer
• • Lack of good morphology blastocysts
• • No evidence for spontaneous follicle development (no dominant (\>17 mm) follicle by day 20 of cycle)
• • Patient with a history of recurrent miscarriages
• • Presence of a hydrosalpinx
• • Irregular uterine cavity
• • Positive test for HIV, hepatitis B or C
• • Lack of consent