Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles
Launched by DUNAMENTI REK ISTENHEGYI IVF CENTER · Mar 11, 2025
Trial Information
Current as of April 23, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Aim: The aim of this RCT is to assess whether the use of luteal support improves the outcome of modified natural cycle frozen embryo transfer (FET) treatments.
Background: Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product. In the follicular phase the increasing amount of estradiol secreted by the growing follicle builds up the endometrium, while in the luteal phase progesterone, the main product of the corpus luteum, prepares the endometrium for implantation...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Age 18-40 years at the time of vitrification
- • At least one good quality blastocyst frozen
- • Planned 1 blastocyst transfer
- • \<3 failed previous ETs
- • Cycle length between 21-35 days
- • Body mass index (BMI): 18-35 kg/m2
- • Intact uterine cavity based on hysteroscopy, hysteron-salpingogram, salina sonohysterogram
- • Consent to participate
- Exclusion Criteria:
- • Age \<18 of over 40 at the time of vitrification
- • BMI: \<18 kg/m2 or \>35 kg/m2
- • Planned transfer of more than 1 embryo
- • Irregular cycles (\<21 or \>35 days)
- • Use of a protocol other than the modified natural cycle frozen embryo transfer
- • Lack of good morphology blastocysts
- • No evidence for spontaneous follicle development (no dominant (\>17 mm) follicle by day 20 of cycle)
- • Patient with a history of recurrent miscarriages
- • Presence of a hydrosalpinx
- • Irregular uterine cavity
- • Positive test for HIV, hepatitis B or C
- • Lack of consent
About Dunamenti Rek Istenhegyi Ivf Center
Dunamenti Rek Isztenhegyi IVF Center is a leading clinical trial sponsor specializing in reproductive health and assisted reproductive technologies. With a commitment to advancing scientific research and improving patient outcomes, the center conducts innovative trials that focus on fertility treatments and related conditions. Equipped with state-of-the-art facilities and a team of experienced professionals, Dunamenti Rek Isztenhegyi IVF Center ensures the highest standards of care and rigorous adherence to ethical protocols in its clinical research endeavors. The center's mission is to contribute to the global body of knowledge in reproductive medicine while providing compassionate support to individuals and families seeking fertility solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported