Identification of B Regulatory Cells by Flow Cytometry

Launched by HULL UNIVERSITY TEACHING HOSPITALS NHS TRUST · Mar 13, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how certain immune cells, known as B-regulatory cells, change in people who have allergies to pollen or insect venom. Researchers want to see if measuring these cells in the blood can help them determine whether patients are responding well to allergen immunotherapy, which is a treatment aimed at reducing allergic reactions over time. Essentially, they are trying to find out if changes in the number of B-regulatory cells indicate that a patient is developing a tolerance to allergens and experiencing fewer allergy symptoms when exposed to them again.

To participate in this study, you need to be 18 years or older. There are two groups of participants: one group includes individuals who do not have any allergies, while the other group includes those with a diagnosed allergy to pollen, house dust mites, or insect venom. Throughout the study, participants will fill out questionnaires about their quality of life and allergy symptoms to see how these relate to the levels of B-regulatory cells. It's important to note that this trial is not yet recruiting participants, and candidates will need to understand the study information provided in English.

Gender

ALL

Eligibility criteria

• Control cohort - Participants with:
• • No clinical and laboratory findings of IgE-mediated hypersensitivity (i.e. no clinical history of specific allergies to pollens, house dust mite or insect venoms
• • Negative serological testing for specific IgE to pollens, house dust mite and insect venoms
• • Patients aged 18 years or older
• Test cohort:
• • Participants over the age of 18 years
• • Participants with physician-diagnosed IgE-mediated allergic disease to pollens, house dust mite or insect venoms
• Exclusion Criteria:
• • Patients under the age of 18 years
• • Samples from patients with IgE-mediated allergic disease, treated or untreated, specific to allergens other than pollens, house dust mite and insect venom
• • Participants who are pregnant
• • Participants who cannot adequately understand verbal and / or written explanations given in English