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Search / Trial NCT06877442

Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders

Launched by ASSIUT UNIVERSITY · Mar 10, 2025

Trial Information

Current as of April 23, 2025

Not yet recruiting

Keywords

Mood Disorders Neurofilament Light Chain

ClinConnect Summary

Cytoskeletal integrity, represented by neurofilament light chain (NfL), has emerged as a critical biomarker for neuroaxonal injury, with growing evidence linking it to mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Neurofilaments are structural proteins essential for maintaining neuronal stability, and NfL, the smallest subunit, is released into extracellular fluids like cerebrospinal fluid (CSF) and blood following neuronal damage. Recent advancements in immunoassay technologies have enabled the reliable quantification of NfL in peripheral blood, providin...

Gender

ALL

Eligibility criteria

  • Participants will be divided into three groups (A) Patients with Major depressive episode (B) Patients with Bipolar Disorder Manic Episode
  • 1. Inclusion criteria:
  • 1. age 15-50 years old
  • 2. both sexes will be included
  • 3. meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for major depressive disorder or Bipolar disorder
  • 2. Exclusion criteria:
  • 1. Major Medical or Neurological Diseases.
  • 2. History of Traumatic Brain Injury, Major Fracture.
  • 3. Alcohol or Substance Use Disorder. (C) Healthy control
  • a. Inclusion criteria:
  • 1. age- and sex-matching with group A, B
  • 2. Healthy Control without any of major physical conditions or psychiatric disorder

Trial Officials

Wageeh A Hassan

Study Chair

Assiut University

Hossam E Khalifa

Study Director

Assiut University

About Assiut University

Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.

Locations

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported