Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders
Launched by ASSIUT UNIVERSITY · Mar 10, 2025
Trial Information
Current as of April 23, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Cytoskeletal integrity, represented by neurofilament light chain (NfL), has emerged as a critical biomarker for neuroaxonal injury, with growing evidence linking it to mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Neurofilaments are structural proteins essential for maintaining neuronal stability, and NfL, the smallest subunit, is released into extracellular fluids like cerebrospinal fluid (CSF) and blood following neuronal damage. Recent advancements in immunoassay technologies have enabled the reliable quantification of NfL in peripheral blood, providin...
Gender
ALL
Eligibility criteria
- • Participants will be divided into three groups (A) Patients with Major depressive episode (B) Patients with Bipolar Disorder Manic Episode
- 1. Inclusion criteria:
- • 1. age 15-50 years old
- • 2. both sexes will be included
- • 3. meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for major depressive disorder or Bipolar disorder
- 2. Exclusion criteria:
- • 1. Major Medical or Neurological Diseases.
- • 2. History of Traumatic Brain Injury, Major Fracture.
- • 3. Alcohol or Substance Use Disorder. (C) Healthy control
- a. Inclusion criteria:
- • 1. age- and sex-matching with group A, B
- • 2. Healthy Control without any of major physical conditions or psychiatric disorder
Trial Officials
Wageeh A Hassan
Study Chair
Assiut University
Hossam E Khalifa
Study Director
Assiut University
About Assiut University
Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported