Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders

Launched by ASSIUT UNIVERSITY · Mar 10, 2025

Keywords

ClinConnect Summary

Cytoskeletal integrity, represented by neurofilament light chain (NfL), has emerged as a critical biomarker for neuroaxonal injury, with growing evidence linking it to mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Neurofilaments are structural proteins essential for maintaining neuronal stability, and NfL, the smallest subunit, is released into extracellular fluids like cerebrospinal fluid (CSF) and blood following neuronal damage. Recent advancements in immunoassay technologies have enabled the reliable quantification of NfL in peripheral blood, providin...

Gender

ALL

Eligibility criteria

• • Participants will be divided into three groups (A) Patients with Major depressive episode (B) Patients with Bipolar Disorder Manic Episode
• 1. Inclusion criteria:
• • 1. age 15-50 years old
• • 2. both sexes will be included
• • 3. meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for major depressive disorder or Bipolar disorder
• 2. Exclusion criteria:
• • 1. Major Medical or Neurological Diseases.
• • 2. History of Traumatic Brain Injury, Major Fracture.
• • 3. Alcohol or Substance Use Disorder. (C) Healthy control
• a. Inclusion criteria:
• • 1. age- and sex-matching with group A, B
• • 2. Healthy Control without any of major physical conditions or psychiatric disorder

Trial Officials