Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders

Launched by ASSIUT UNIVERSITY · Mar 10, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to understand how a specific protein called neurofilament light chain, found in the blood, relates to the severity of symptoms and cognitive decline in people with mood disorders like major depressive disorder and bipolar disorder. Researchers want to see if measuring this protein can help detect these mood disorders earlier and provide insights into how they progress over time.

To take part in the study, participants need to be between 15 and 50 years old and meet certain criteria for having a major depressive episode or a manic episode of bipolar disorder. Healthy individuals of the same age and gender without any major health issues will also be included as a control group. Those who have significant medical conditions, a history of serious head injuries, or substance abuse problems will not be eligible. Participants can expect to undergo assessments to measure their symptoms and cognitive abilities, helping researchers learn more about the relationship between these factors and the neurofilament light chain. This could ultimately lead to better ways to diagnose and treat mood disorders in the future.

Gender

ALL

Eligibility criteria

• • Participants will be divided into three groups (A) Patients with Major depressive episode (B) Patients with Bipolar Disorder Manic Episode
• 1. Inclusion criteria:
• • 1. age 15-50 years old
• • 2. both sexes will be included
• • 3. meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for major depressive disorder or Bipolar disorder
• 2. Exclusion criteria:
• • 1. Major Medical or Neurological Diseases.
• • 2. History of Traumatic Brain Injury, Major Fracture.
• • 3. Alcohol or Substance Use Disorder. (C) Healthy control
• a. Inclusion criteria:
• • 1. age- and sex-matching with group A, B
• • 2. Healthy Control without any of major physical conditions or psychiatric disorder