Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath

Launched by BEIJING 302 HOSPITAL · Mar 10, 2025

Keywords

ClinConnect Summary

Acute upper gastrointestinal bleeding (AUGIB) is a common emergency with an annual incidence of 100-180/100,000 and mortality of 2%-15%. Endoscopy, the gold standard, is invasive and equipment-dependent, limiting its use in primary care or emergencies. Exhaled breath VOCs analysis, a non-invasive and portable method, has been applied in other diseases but not yet explored for AUGIB.

Objectives:

1. Identify characteristic VOC profiles in exhaled breath of AUGIB patients.
2. Develop a VOC-based predictive model with sensitivity and specificity ≥0.7.
3. Establish rapid diagnostic criteria to...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years;
• • 2. Clinical suspicion of AUGIB (e.g., hematemesis, melena);
• • 3. Fasting ≥4 hours;
• • 4. Signed informed consent.
• Exclusion Criteria:
• • 1. Severe pulmonary dysfunction or recent lung infection (within 1 week);
• • 2. Cardiac/renal failure or disseminated intravascular coagulation;
• • 3. Contraindications to endoscopy;
• • 4. High-risk conditions (e.g., massive ascites);
• • 5. Alcohol consumption within 24 hours;
• • 6. Pregnancy.