Reducing Risk of Stroke and DementIa in PatientS with COVert CERebrovascular Disease

Launched by UNIVERSITY OF EDINBURGH · Mar 13, 2025

Keywords

ClinConnect Summary

DISCOVER is a prospective cohort involving individuals with covert cerebrovascular disease (CCD) in NHS Lothian. Participants will be recruited through electronic health records and clinician collaborators. Participants will be monitored at 3 and 6 months and where possible 12 months to assess cognitive, functional, and vascular event outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • People who, at the time the letter is prepared or are identified by a clinician
• • Age ≥ 65 years
• * Have no known history of:
• • Stroke or TIA
• • Dementia
• • Parkinson's disease
• • Multiple sclerosis
• • Metastatic cancer (or non-meningioma brain tumour).
• * A CT or MRI scan report ≤5 years before study start date with of one or more of:
• • Cerebral small vessel disease
• • Deep old ischaemic stroke
• • Cortical old ischaemic stroke
• Exclusion Criteria:
• • Text of brain scan report unreadable
• • Do not consent to take part in study procedures
• • Unable to consent
• • Unable to communicate by email, letter or telephone through language, speech disability or lack of address
• • Unlikely to survive one year past enrolment in judgement of the study investigator