Nitrate - Clopidogrel - Acute Coronary Syndrome

Launched by BURSA POSTGRADUATE HOSPITAL · Mar 13, 2025

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • diagnosed with non-STEMI
• • Patients aged 18 to 75 years
• • positive troponin levels,
• • blood pressure above 120/70 mmHg
• Exclusion Criteria:
• • Hemodynamically unstable and requiring urgent intervention,
• • ST elevation on electrocardiography, atrial fibrillation,
• • recurrent angina,
• • use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
• • history of coronary artery bypass graft (CABG) surgery,
• • active infection,
• • uncontrolled hypertension,
• • diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
• • active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
• • left ventricular systolic dysfunction (ejection fraction \<50%),
• • glomerular filtration rate \<60 mL/min/1.73m2,
• • allergy to ASA or clopidogrel, coagulopathy,
• • platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.