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Search / Trial NCT06878664

Randomized Interval Assessment Trial of Lu177-Dotatate in Slowly Progressive G1-2 Advanced Midgut Neuroendocrine Tumors

Launched by GRUPO ESPANOL DE TUMORES NEUROENDOCRINOS · Mar 10, 2025

Trial Information

Current as of April 22, 2025

Not yet recruiting

Keywords

Midgut Neuroendocrine Tumors Lu177 Dotatate

ClinConnect Summary

1. Rationale The main hypothesis is less intensive somatostatin-receptor (SST) targeted radioligand therapy (RLT) (7.4 GBq/cycle 177Lu-Dotatate every 16 weeks x 4 cycles) is associated with less severe hematological toxicities and may mitigate the risk to develop therapy-related myeloid neoplasms (t-MN) with similar antitumor efficacy in slowly growing gastrointestinal grade 1-2 NETs.
2. Objectives Primary Objectives

-To demonstrate decreased serious hematological toxicity with a less intensive RLT regimen in slowly progressive advanced Grade 1-2 midgut NETs.

Secondary Objectives
...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. Patients who have histologically confirmed diagnosis of unresectable, advanced or metastatic midgut NETs (originated in the jejunum-ileum or right colon) who are candidates to receive 177Lu-Dotatate targeted radioligand therapy (RLT) and SSA. Patients with a large SRI+ mesenteric mass with abdominal-dominant disease judged by the investigator to be a midgut NET will also be eligible.
  • 2. Ki-67 index ≤ 20%.
  • 3. Disease progression per RECIST v1.1 within 36 months prior to study entry,
  • 4. Patients may be treatment naïve (first-line) or have received prior systemic therapy except for any type of prior RLT (not restricted to 177Lu-Dotatate).
  • 5. In somatostatin receptor (SSTR) imaging all RECIST v1.1 evaluable target lesions and non-target lesions need to be SSTR positive (SSTR+) as defined by equal or above the liver uptake (this includes lesions of at least 10 mm in diameter in CT or MRI). If an FDG PET is performed (not mandatory), all FDG PET positive lesions should also be somatostatin receptor positive in SSRT imaging (see guidance Appendix 10).
  • 6. Measurable disease according to RECIST v1.1 criteria (Appendix 3)
  • 7. Adequate organ function (hematological, renal and liver) based upon meeting all of the following laboratory criteria:
  • Neutrophil count (ANC) ≥ 2.000/mm3
  • Platelet count ≥ 75 × 109/L
  • Hemoglobin ≥ 8 g/dL
  • Serum bilirubin ≤ 3.0 × upper limit of normal (ULN) or ≤ 3 × ULN for subjects with Gilbert's disease
  • Serum albumin \<3.0 g/dL unless prothrombin time is within the normal range.
  • Creatinine clearance (CrCl) ≥ 50 mL/min as estimated by the Cockroft-Gault formula or as measured by 24-hour urine collection (GFR can also be used instead of CrCl). Note: renal tract obstruction is not allowed.
  • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN or ≤ 5 xULN for subjects with liver metastases
  • 8. Karnofsky performance status (KPS) scale ≥ 70%
  • 9. Patient information and signing of the consent form, Institutional Review Board(IRB)/Independent Ethics Committee (IEC) approved, before any study-specific procedure. The patient must be able and willing to cooperate in monitoring study visits and procedures.
  • 10. Patients ≥ 18 years of age.
  • 11. Recovery to Grade ≤ 1 from any adverse event (AE) from prior treatment (excluding alopecia and/or asthenia).
  • 12. Life expectancy ≥ 12 months.
  • 13. Patients with health coverage (public or private), that includes coverage for patients enrolled in clinical trials, to both study treatments and determinations/procedures.
  • 14. Female subject must provide a negative urine pregnancy test at screening, and must agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%; refer to Appendix 4) for the duration of the study treatment and for 7 months after the final dose of study treatment. Sexually active men must agree to use the male condom during the study and until at least 7 months after the last administration of treatment. Additionally, it is recommended that your female partner of childbearing age use a highly effective method of contraception.
  • 15. Subject agrees not to participate in another interventional study while on treatment in the present study.
  • Exclusion Criteria:
  • 1. Patients who have known hypersensitivity to lutetium-177 (177Lu), oxodotreotide, DOTA, somatostatin analogues, lysine, arginine, or any excipient/derivative of these agents
  • 2. Prior external beam radiation therapy (EBRT) to more than 25% of the bone marrow
  • 3. Prior whole liver internal radiation therapy (SIRT)
  • 4. Prior radioligand therapy (RLT) (not restricted to 177Lu-Dotatate).
  • 5. Prior major surgery, systemic therapy, embolization or other locoregional treatments within 4 weeks of study entry
  • 6. Patients who have a known active Hepatitis B (e.g., HBsAg reactive) or active hepatitis C (e.g., HCV RNA \[qualitative\] is detected). Patients who have a known active history of human immunodeficiency virus (HIV) infection (HIV 1 or 2).
  • 7. Other known malignancies unless cured or definitively treated with no evidence of recurrence for 3 years
  • 8. Serious non-malignant disease (e.g. psychiatric, infectious, autoimmune, cardiovascular or dementia), that may interfere with the objectives of the trial or with the safety or compliance of the patient, as judged by the investigator.
  • 9. Female patients must agree not to breastfeed or donate ovules starting at screening and throughout the study period, and for at least 7 months after the final study drug administration.
  • 10. Male patients must agree not to donate sperm starting at screening and throughout the study period, and for at least 4 months after the final study drug administration.
  • 11. Pregnancy or lactation. Men and women should not procreate during study treatment and until seven months after the final study drug administration.
  • 12. For female patients of childbearing potential (defined as \< 2 years after last menstruation and not surgically sterile) and male patients who are not surgically sterile and have female partners of childbearing potential that do not agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%; refer to Appendix 4) for the duration of the study treatment and for 7 months after the final dose of study treatment
  • 13. Patient under guardianship or curatorship or deprived of liberty by a judicial or administrative decision or patient unable to give consent.

Trial Officials

Rocio Garcia Carbonero Garcia Carbonero, M.D., Ph.D.

Study Director

Hospital Universitario 12 de Octubre

Eric Baudin Baudin, M.D., Ph.D.

Study Director

Gustave Roussy, Cancer Campus, Grand Paris

About Grupo Espanol De Tumores Neuroendocrinos

The Grupo Español de Tumores Neuroendocrinos (GETNE) is a leading Spanish organization dedicated to advancing research, treatment, and education related to neuroendocrine tumors (NETs). Comprising a multidisciplinary network of healthcare professionals, including oncologists, endocrinologists, and researchers, GETNE focuses on improving patient outcomes through collaborative clinical trials, innovative therapeutic strategies, and comprehensive clinical guidelines. The group's commitment to fostering knowledge sharing and promoting best practices in the management of NETs positions it at the forefront of clinical research and patient care in this specialized field.

Locations

Madrid, , Spain

Madrid, , Spain

Valencia, , Spain

Madrid, , Spain

Madrid, , Spain

Sevilla, , Spain

Caen, , France

Rennes, , France

Paris, , France

Barcelona, , Spain

Dijon, , France

Marseille, , France

Valencia, , Spain

Santiago De Compostela, La Coruña, Spain

Oviedo, Asturias, Spain

Lyon, , France

Granada, , Spain

Clichy, Paris, France

Lille, , France

Burgos, Baleares, Spain

L'hospitalet De Llobregat, Barcelona, Spain

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported