Study of Congenital Orofacial Clefts by Implementing Optical Genome Mapping

Launched by CENTRE HOSPITALIER UNIVERSITAIRE, AMIENS · Mar 11, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the genetic causes of congenital orofacial clefts, which are common birth defects that affect the face and mouth. The researchers are using a new technology called optical genome mapping (OGM) to look for specific changes in a person’s DNA that may not be detected by traditional methods. By identifying these genetic variations in individuals with orofacial clefts who do not have a known genetic diagnosis, the study aims to better understand the causes of these conditions and improve future diagnoses and treatments.

To participate in this study, individuals must have syndromic, complex, or familial orofacial clefts and must not already have a genetic diagnosis. They should be under the care of the Amiens-Picardie University Hospital. Unfortunately, people with a known genetic diagnosis of orofacial clefts or certain legal restrictions, as well as pregnant or breastfeeding women, are not eligible. Participants will have the opportunity to contribute to important research that could help uncover the genetic factors behind orofacial clefts, which may lead to improved understanding and care for others with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals with syndromic, complex or familial oral-facial clefts
• • With no established genetic diagnosis
• • Followed up at the Amiens-Picardie University Hospital
• Exclusion Criteria:
• • genetic diagnosis of oral-facial cleft
• • No health insurance affiliation
• • Patient under guardianship or curatorship, under safeguard of justice or deprived under public law
• • Pregnant, parturient or breast-feeding woman