A Study of mRNA-4106 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Solid Tumors

Launched by MODERNATX, INC. · Mar 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called mRNA-4106, which is being tested alone and with another type of therapy known as immune checkpoint inhibitors. The goal is to see if mRNA-4106 is safe and well-tolerated in patients with advanced solid tumors, which are cancers that have spread in the body. The trial is not currently recruiting participants, but it is looking for adults aged 65 to 74 who have specific types of advanced cancer, such as melanoma or lung cancer, and who have either completed or refused standard treatments.

To participate, individuals must have measurable cancer that can be assessed and have a tumor that can be biopsied or provide previous tumor samples. They should also be in generally good health and not currently receiving certain other cancer treatments. Participants will not be able to join if they have certain active brain tumors, have recently taken other cancer therapies, or have specific medical conditions that could affect their ability to participate. Those who qualify will have the opportunity to help researchers learn more about this potential new treatment for advanced cancers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Arm 1, Monotherapy Arm: Histologically confirmed advanced or metastatic cancer (melanoma, non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), esophageal carcinoma, head and neck squamous cell carcinoma (HNSCC), urinary bladder cancer (UBC), colon/rectal adenocarcinomas, gastric, ovarian, cervical, and endometrial carcinomas) with measurable disease as determined by RECIST v1.1 and have completed or refused all standard therapies (no limit to prior lines of therapy). Participants must have a tumor lesion amenable to biopsy, or alternatively archival tumor tissue is acceptable as long as the collection date is within one year of the enrollment date.
• • Arm 2, Combination with Nivolumab/Relatlimab Arm: Histologically confirmed unresectable or metastatic melanoma, with measurable disease as determined by RECIST v1.1 and have not had any prior therapy for this cancer in this setting (that is, first-line therapy). Note that prior adjuvant, neoadjuvant, or perioperative melanoma therapy (that is, anti-CTLA-4, anti-PD1/L1, BRAF/MEK inhibitors, or interferon) is permitted if disease recurrence did not occur within 3 months from the last treatment date.
• • Participant has an Eastern Cooperative Oncology Group (ECOG) performance status of ≤1.
• • Participant has adequate hematological and biological function.
• • Participants who could become pregnant: negative pregnancy test within 24 hours before the first dose of study treatment.
• Exclusion Criteria:
• • Participant has active central nervous system tumors or metastases
• • Participant has received treatment with prohibited medications/treatments (ie, concurrent anticancer therapy including other chemotherapy, hormonal anticancer therapy, biologic therapy, or immunotherapy) or investigational agents within 5 half-lives or 14 days prior to the first day of study treatment (Cycle 1 Day 1), whichever is shorter.
• • Participant has required the use of immunosuppressive doses of systemic steroids or absorbed topical steroids (doses \>10 mg prednisone daily equivalent) within 2 weeks before study treatment administration or currently requiring maintenance doses of \>10 mg prednisone or equivalent per day.
• • Participant has any plan to receive a live attenuated vaccine during study treatment or has received a live vaccine within 30 days before the first dose of study treatment.
• • Participant has reversible toxicities from prior cancer therapy that have not recovered to Grade 1 or baseline. Any unresolved toxicity National Cancer Institute (NCI) Common Terminology Criteria for AEs (CTCAE) Grade ≥2 from previous anticancer therapy with the exception of alopecia, vitiligo, and prespecified laboratory values.
• • Participant has any unstable or clinically significant concurrent medical/psychiatric illness or social situation that would limit compliance with study requirements or compromise the ability of the participant to provide written informed consent, per the discretion of the Investigator.
• • Participant has concurrent enrollment in another clinical study (unless it is an observational noninterventional clinical study).
• • Note: Other inclusion and exclusion criteria may apply.