Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit

Launched by POMERANIAN MEDICAL UNIVERSITY SZCZECIN · Mar 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how changes in DNA can help us understand and predict complications in patients who have experienced a type of bleeding in the brain known as aneurysmal subarachnoid hemorrhage (aSAH). The researchers want to find out if there are specific DNA changes in the blood of patients with aSAH that can tell us apart from healthy individuals, and if these changes can predict the risk of developing delayed ischemic neurologic deficit (DIND), a serious condition that can occur after aSAH.

To participate in this study, individuals must be adults who have been diagnosed with aSAH, confirmed by a CT scan, and have had a ruptured aneurysm treated. Participants will have a blood sample taken shortly after being admitted to the hospital, and their health will be monitored for any signs of DIND. The goal is to identify potential markers that could help doctors diagnose and manage patients with aSAH more effectively. If you or a loved one fits the eligibility criteria and is interested in learning more, please speak with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • subarachnoid hemorrhage in computed tomography (CT) scan
• • ruptured aneurysm identified with angio-CT or digital subtraction angiography (DSA)
• • aneurysm successfully embolized or clipped
• • obtained informed consent
• • Hunt-Hess grade ≤ 3 by day 14 (initial higher grade was allowed providing that patient improved to grade 3 or higher by day 14)
• Exclusion Criteria:
• • \< 18 years old
• • unable to sign informed consent
• • diagnosis of idiopathic perimesencephalic subarachnoid hemorrhage
• • aneurysm identified more than 14 days after the ictus
• • more than 14 days at the Intensive Care Unit
• • remaining in Hunt Hess grade 5 or World Federation of Neurological Surgeons (WFNS) grade 5 from admission up to post-bleeding day 14