Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients
Launched by TANTA UNIVERSITY · Mar 11, 2025
Trial Information
Current as of April 23, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is examining the effectiveness of a combination of Tranexamic acid and vitamin K injections in helping to control upper gastrointestinal bleeding (UGIB) in patients with cirrhosis, a serious liver condition. Researchers want to see if this treatment can reduce bleeding and improve survival rates compared to a placebo, which is a harmless saline solution. The study will include adults aged 18 and older who have liver cirrhosis and are experiencing UGIB. However, it will not include those with certain allergies, pregnancy, or serious kidney issues.
If you or a loved one participates, you will receive either the active treatments or the placebo, along with standard care for your condition. All participants will stay in the hospital for at least 5 days for monitoring after the bleeding episode, and follow-up visits will occur at 6 weeks to check for any rebleeding or related health issues. If everything goes well, you may be discharged with instructions to monitor your health and return to the hospital if you experience any concerning symptoms.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age ≥18 years
- • Liver cirrhosis
- • Upper gastrointestinal bleeding
- Exclusion Criteria:
- • Patients aged \< 18 years
- • Allergy to tranexamic acid
- • Allergy to vitamin K injection
- • DIC.
- • Thromboembolic event.
- • Pregnancy or lactation.
- • End-stage renal disease.
- • Unwilling to participate in our study.
Trial Officials
Rania M Elkafoury, MD
Principal Investigator
Tropical medicine and infectious diseases Department, Faculty of Medicine, Tanta University
About Tanta University
Tanta University is a prestigious academic institution located in Egypt, dedicated to advancing medical research and education. As a clinical trial sponsor, Tanta University leverages its extensive resources and expertise to conduct innovative research initiatives aimed at improving health outcomes. The university collaborates with a network of healthcare professionals, researchers, and institutions to facilitate rigorous clinical trials across various medical disciplines. Committed to ethical standards and scientific integrity, Tanta University strives to contribute to the global body of knowledge while fostering the next generation of medical professionals.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tanta, Gharbyea, Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported