Intermittent Fasting Diet Versus Resistive Exercise Program on Insulin Resistance in Obese Women With P.C.O.S

Launched by CAIRO UNIVERSITY · Mar 12, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to find out which method is better for improving insulin resistance in obese women with Polycystic Ovary Syndrome (PCOS): an intermittent fasting diet or a resistive exercise program. Insulin resistance means your body has trouble using insulin effectively, which can lead to various health issues. The study will involve 72 women between the ages of 25 and 40 who have been diagnosed with PCOS and are considered overweight or obese.

To join the trial, participants must meet certain criteria, including having a BMI (body mass index) over 25 but under 30, and not having other serious health conditions that could interfere with the study. Participants can expect to follow either the fasting diet or the exercise program for a set period and will be monitored throughout the trial. This research is important as it aims to find effective ways to help women with PCOS manage their condition better. Please note that the study is not yet recruiting participants.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Seventy two obese women diagnosed with Polycystic ovarian syndrome by the gynecologist (based on the Rotterdam diagnostic criteria)
• • Their age will range from 25 to 40 years old.
• • Overweight or obese (BMI \>25 kg/m2 and \< 30 kg/m2).
• Exclusion Criteria:
• • The presence of diseases (such as congenital adrenal hyperplasia, Cushing syndrome, androgen secreting tumors, hyperprolactinemia, diabetes, thyroid diseases, Severe serious cardiovascular, gastrointestinal, kidney and liver diseases. premature ovarian failure, hypothalamic/pituitary disease
• • Hormonal contraceptive use.
• • Participants who did not complete the study were excluded from the analysis.
• • Use of medication therapy that impacts carbohydrate or lipid metabolism (oral contraceptive pills, insulin sensitizers, anti epileptics, anti psychotics, statins, and fish oil) in the recent 6 months;
• • Body weight fluctuations for more than 5% in the past 3 months; in preparation for pregnancy.
• • Perimenopausal; night shift workers; fasting for more than 16 h per day; hypotension
• • Alcohol intake for more than 100 g per week; smoking within the past 3 months
• • Engaging in high intensity exercise.