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Search / Trial NCT06882668

Role of Cardiovascular Imaging in the Early Diagnosis of Hypertrophic Cardiomyopathy in Women

Launched by IRCCS SAN RAFFAELE · Mar 12, 2025

Trial Information

Current as of April 23, 2025

Active, not recruiting

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Able to sign informed consent.
  • First-degree relatives of HCM patients already in follow-up at the participating centres, independently from the genetic status of the affected family member.
  • Unselected subjects referred to the Cardiomyopathy Outpatient Clinics with clinical suspicion of HCM.
  • Availability to perform transthoracic echocardiographic imaging, and to perform CMR.
  • Exclusion Criteria:
  • Known history of systemic hypertension with documented secondary LV heart disease.
  • Known grown up congenital heart disease patients with documented secondary LV hypertrophy.
  • Known hemodynamically relevant valvular diseases with documented secondary LV hypertrophy.
  • Known HCM phenocopies: infiltrative diseases mimicking HCM (cardiac amyloidosis, haemochromatosis and secondary hemosiderosis), metabolic storage diseases (Anderson-Fabry disease, Pompe disease, Danon disease, PRKAG2-related disease).
  • Neuromuscular diseases as Friedreich ataxia, distrophinopathies and desminopathies.
  • Known mitochondrial diseases with documented myocardial involvement.
  • Known malformation syndromes as RAS/MAPK disorders (Noonan syndrome, LEOPARD syndrome, Costello syndrome), cardiofaciocutaneous syndrome.
  • Previous long-term treatment with tacrolimus, hydroxychloroquine, steroids.
  • Known absolute contraindications to CMR.

About Irccs San Raffaele

IRCCS San Raffaele is a prestigious research hospital and clinical trial sponsor based in Milan, Italy, renowned for its commitment to advancing medical science through innovative research and high-quality patient care. As an Institute for Research and Healthcare, it specializes in a wide range of therapeutic areas, including oncology, neurology, and cardiology, and is dedicated to translating scientific discoveries into effective clinical practices. With a multidisciplinary team of experts and state-of-the-art facilities, IRCCS San Raffaele plays a pivotal role in conducting rigorous clinical trials that contribute to the development of novel treatments and improve patient outcomes globally.

Locations

Milan, , Italy

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported