Role of Cardiovascular Imaging in the Early Diagnosis of Hypertrophic Cardiomyopathy in Women
Launched by IRCCS SAN RAFFAELE · Mar 12, 2025
Trial Information
Current as of April 23, 2025
Active, not recruiting
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Able to sign informed consent.
- • First-degree relatives of HCM patients already in follow-up at the participating centres, independently from the genetic status of the affected family member.
- • Unselected subjects referred to the Cardiomyopathy Outpatient Clinics with clinical suspicion of HCM.
- • Availability to perform transthoracic echocardiographic imaging, and to perform CMR.
- Exclusion Criteria:
- • Known history of systemic hypertension with documented secondary LV heart disease.
- • Known grown up congenital heart disease patients with documented secondary LV hypertrophy.
- • Known hemodynamically relevant valvular diseases with documented secondary LV hypertrophy.
- • Known HCM phenocopies: infiltrative diseases mimicking HCM (cardiac amyloidosis, haemochromatosis and secondary hemosiderosis), metabolic storage diseases (Anderson-Fabry disease, Pompe disease, Danon disease, PRKAG2-related disease).
- • Neuromuscular diseases as Friedreich ataxia, distrophinopathies and desminopathies.
- • Known mitochondrial diseases with documented myocardial involvement.
- • Known malformation syndromes as RAS/MAPK disorders (Noonan syndrome, LEOPARD syndrome, Costello syndrome), cardiofaciocutaneous syndrome.
- • Previous long-term treatment with tacrolimus, hydroxychloroquine, steroids.
- • Known absolute contraindications to CMR.
About Irccs San Raffaele
IRCCS San Raffaele is a prestigious research hospital and clinical trial sponsor based in Milan, Italy, renowned for its commitment to advancing medical science through innovative research and high-quality patient care. As an Institute for Research and Healthcare, it specializes in a wide range of therapeutic areas, including oncology, neurology, and cardiology, and is dedicated to translating scientific discoveries into effective clinical practices. With a multidisciplinary team of experts and state-of-the-art facilities, IRCCS San Raffaele plays a pivotal role in conducting rigorous clinical trials that contribute to the development of novel treatments and improve patient outcomes globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Milan, , Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported