The Immediate Effect of Applying Transcutaneous Electrical Nerve Stimulation (TENS) on Sympathetic Ganglion and Gastrocnemius for Popliteal Blood Flow

Launched by KAOHSIUNG MEDICAL UNIVERSITY · Mar 17, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a treatment called Transcutaneous Electrical Nerve Stimulation (TENS) affects blood flow in the leg, specifically in the area behind the knee known as the popliteal region. TENS is often used to help relieve pain, but researchers want to see if it can also improve blood flow, especially for people who have conditions that make it hard for blood to circulate properly, like diabetes or obesity. The study will compare different ways of using TENS, looking at how the frequency of stimulation and the location on the body may change its effectiveness.

To participate in this trial, you need to be a healthy adult aged 18 or older with a body mass index (BMI) between 18.5 and 24. However, some people may not be eligible if they have certain health issues, like metal implants, open wounds, or if they smoke. If you join the trial, you can expect to undergo two sessions of TENS treatment over a week. The goal is to find out the best way to use TENS to help improve blood flow, which could one day offer a new option for those with circulation problems.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Healthy people
• • 2. Age: 18 years and above (inclusive)
• • 3. Body mass index (BMI) between 18.5 and 24
• Exclusion Criteria:
• • 1. Unable to complete two interventions within a week
• • 2. Have contraindications to electrotherapy (for example: metal implants in the body, open wounds, pregnancy, sensory loss)
• • 3. Obvious varicose veins 4. Unable to lie down for about 1 to 2 hours 5. Taking drugs or nutritional supplements that affect autonomic nervous activity or vasodilation (for example: Ginkgo biloba) 6. Smoking 7. Ankle and Ankle Index (ABI) less than 0.9 or greater than 1.3