The Effects of Tyrosol and Creatine on Endurance, Strength, and Fatigue Resistance in Healthy Adults

Launched by APPLIED SCIENCE & PERFORMANCE INSTITUTE · Mar 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two substances, tyrosol and creatine, on physical performance, including endurance (how long you can exercise), strength (how much weight you can lift), and resistance to fatigue (how long you can keep going without getting tired). Over four weeks, participants will take one of four options: tyrosol, a placebo (a substance with no active ingredient), creatine, or a combination of both tyrosol and creatine. Researchers will measure how these substances affect different physical abilities through various tests at the beginning and end of the study.

To participate, you should be a healthy adult aged 18 to 50 who exercises regularly (at least twice a week) and meets certain health criteria. You will need to agree not to take other supplements that could affect your muscle strength or endurance during the study. If you join, you can expect to have your body composition, strength, and endurance tested multiple times, along with completing questionnaires about how you feel. This trial is a great opportunity to help researchers learn more about how tyrosol and creatine may work together to improve athletic performance.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy males or females aged 18-50
• • Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
• • Estimated VO2 max equal to or greater than the 50th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
• • Able to read and write in English
• • During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
• • Females willing to share days menstrual cycle for testing purposes as shifts in hormone levels may, potentially, affect testing
• Exclusion Criteria:
• • Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
• • Recent musculoskeletal injury (\<3-months)
• • Recent orthopaedic surgery (\<12-months)
• • History or current malignancy
• • Previous gastrointestinal surgery within the past 12 months
• • Regular smoker
• • Regular drinker (\>14 drinks per week)
• • Current use (within the past 4 weeks) of creatine supplements
• • Current use (within past 3 months) of Tyrosol supplementation
• • Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).
• • Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)
• • Female subjects who do not test negative on a urine pregnancy test or are lactating.