Laparoscopic Interval Cytoreductive Surgery in Advance Ovarian Cancer

Launched by INSTITUTO NACIONAL DE CANCEROLOGIA DE MEXICO · Mar 12, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to perform surgery for women with advanced ovarian cancer. Specifically, it compares a less invasive type of surgery called laparoscopic surgery to traditional open surgery. The goal is to see if laparoscopic surgery can provide the same benefits as open surgery for patients who have already received chemotherapy before surgery. This approach may help patients recover faster and continue with their additional treatments more easily.

To participate in this trial, women aged 18 to 75 who have been diagnosed with stage III or IV ovarian cancer may be eligible, as long as their cancer has responded well to chemotherapy. They should also have a certain level of a tumor marker called CA-125 and have a good overall health status that allows for surgery. However, women with specific complications, such as persistent fluid buildup or certain types of metastasis, won't qualify for the study. Those who join the trial can expect careful monitoring and support throughout the process, helping to ensure they receive the best possible care while contributing to important research.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of epithelial ovarian cancer (all subtypes of epithelial ovarian cancer) in stage III-IV
• • Partial and complete response to treatment with QTNA after 3-4 cycles, evaluated by PET-CT imaging study, patients that the functional unit decides to incorporate into the project.
• • Ca 125 which will have to be less than 200
• • ECOG 0 to 2 without medical contraindication to perform surgery (≤ ASA 2 or ≤ Goldman 2).
• Exclusion Criteria:
• • Partial response with persistence of ascites or pleural effusion.
• • With unresectability criteria (multiple intrahepatic liver metastases, retroperitoneal lymph node conglomerates \>2cm above the renal lymph nodes, metastatic disease above the diaphragm, multiple intestinal involvement and mesentery retraction).