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Search / Trial NCT06884280

Comparing High and Low Dose Iron Treatments for People on Peritoneal Dialysis: The PALaDIN Study

Launched by HULL UNIVERSITY TEACHING HOSPITALS NHS TRUST · Mar 17, 2025

Trial Information

Current as of April 22, 2025

Not yet recruiting

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Males and females aged ≥18 years.
  • Able to give informed consent
  • Serum ferritin \<700ug/L
  • Transferrin saturation level \<40%
  • No intravenous iron for last 4 weeks before randomisation (patients may be pre-identified and included after 4-week washout period)
  • Received maintenance peritoneal dialysis therapy for at least 4 weeks
  • Expected to remain on peritoneal dialysis therapy for duration of study
  • Exclusion Criteria:
  • Inadequate dialysis deemed by responsible clinician
  • Probability of need for transfusion within 1 week of enrolment
  • Anticipated major surgery that the responsible clinician feels will impact response to treatment
  • Haemochromatosis / haemosiderosis or ALT \>x3 normal
  • Are deemed to be most suited to best-supportive or end-of-life care at time of screening
  • Women of childbearing potential not using effective means of contraception
  • Have been involved in another medicinal study (CTIMP) within past 4 weeks
  • Known allergy or adverse reaction to oral or intravenous iron preparations
  • CRP \>50, TSATs \>40%, SF \>700 at time of recruitment
  • Active infection, HIV, active Hep B or C
  • Are unable or unwilling to consent to or complete the study procedures

About Hull University Teaching Hospitals Nhs Trust

Hull University Teaching Hospitals NHS Trust is a leading healthcare organization dedicated to delivering high-quality patient care, education, and research. Located in Hull, England, the Trust encompasses a range of hospitals and healthcare services, providing a comprehensive spectrum of clinical specialties. With a strong commitment to advancing medical science, the Trust actively sponsors and conducts clinical trials that aim to improve patient outcomes and contribute to evidence-based practice. By collaborating with academic partners and leveraging its state-of-the-art facilities, Hull University Teaching Hospitals NHS Trust fosters an innovative research environment that prioritizes patient safety and ethical standards.

Locations

Hull, East Riding Of Yorkshire, United Kingdom

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported