ClinConnect ClinConnect Logo
Search / Trial NCT06884319

Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Predictor of Intracranial Pressure

Launched by BENHA UNIVERSITY · Mar 13, 2025

Trial Information

Current as of April 23, 2025

Active, not recruiting

Keywords

Optic Nerve Sheat Diameter Deformability Index Increase Intra Cranial Pressure

ClinConnect Summary

Operational Design:

Preparation:

Awake and alert patients should be briefed on the procedure. Obtunded, intubated, or heavily sedated patients should undergo a basic eye evaluation for signs and symptoms of globe rupture or hyphema. If there is evidence of globe rupture-including visible conjunctival or scleral defects, severe chemosis, 360-degree conjunctival hemorrhage, hypotony, or total hyphema-the procedure should be aborted to avoid further herniation of intraocular contents, and an ophthalmologist should be consulted. The patient's position should be determined by comfort and ease ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • age 18 to 65 years
  • increased ICP (e.g., TBI, sub arachnoid hemorrhage, intracranial hemorrhage)
  • a Glasgow Coma scale=3-12 and requiring ICP monitoring via invasive methods (e.g. extra ventricular drain, lumber drain)
  • Exclusion Criteria:
  • chronic hydrocephalus
  • extensive local orbit trauma
  • a pre-existing ocular disease affecting the optic nerve and/or orbital cavity
  • hyperthyroidism with exophthalmia
  • facial trauma affecting the orbits and/or eyeballs
  • optic nerve trauma
  • signs of critically raised ICP, needing urgent surgery.
  • hemodynamically unstable between ONSD acquisition and ICP measurement.
  • receiving medication that would decrease ICP between ultrasound imaging and ICP measurement, i.e. mannitol, hypertonic saline or steroids.

Trial Officials

Ahmed Mostafa Abd El-hamed, Professor

Study Director

Benha University

About Benha University

Benha University, a leading institution in Egypt, is dedicated to advancing medical research and innovation through rigorous clinical trials. With a strong emphasis on multidisciplinary collaboration, the university aims to enhance healthcare outcomes by exploring novel therapeutic approaches and interventions. Its state-of-the-art facilities and commitment to ethical research practices ensure that all trials are conducted with the highest standards of integrity and scientific rigor. Benha University actively contributes to the global medical community by fostering partnerships and disseminating findings that can improve patient care and inform public health policies.

Locations

Benha, , Egypt

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported