Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Predictor of Intracranial Pressure
Launched by BENHA UNIVERSITY · Mar 13, 2025
Trial Information
Current as of April 23, 2025
Active, not recruiting
Keywords
ClinConnect Summary
Operational Design:
Preparation:
Awake and alert patients should be briefed on the procedure. Obtunded, intubated, or heavily sedated patients should undergo a basic eye evaluation for signs and symptoms of globe rupture or hyphema. If there is evidence of globe rupture-including visible conjunctival or scleral defects, severe chemosis, 360-degree conjunctival hemorrhage, hypotony, or total hyphema-the procedure should be aborted to avoid further herniation of intraocular contents, and an ophthalmologist should be consulted. The patient's position should be determined by comfort and ease ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • age 18 to 65 years
- • increased ICP (e.g., TBI, sub arachnoid hemorrhage, intracranial hemorrhage)
- • a Glasgow Coma scale=3-12 and requiring ICP monitoring via invasive methods (e.g. extra ventricular drain, lumber drain)
- Exclusion Criteria:
- • chronic hydrocephalus
- • extensive local orbit trauma
- • a pre-existing ocular disease affecting the optic nerve and/or orbital cavity
- • hyperthyroidism with exophthalmia
- • facial trauma affecting the orbits and/or eyeballs
- • optic nerve trauma
- • signs of critically raised ICP, needing urgent surgery.
- • hemodynamically unstable between ONSD acquisition and ICP measurement.
- • receiving medication that would decrease ICP between ultrasound imaging and ICP measurement, i.e. mannitol, hypertonic saline or steroids.
Trial Officials
Ahmed Mostafa Abd El-hamed, Professor
Study Director
Benha University
About Benha University
Benha University, a leading institution in Egypt, is dedicated to advancing medical research and innovation through rigorous clinical trials. With a strong emphasis on multidisciplinary collaboration, the university aims to enhance healthcare outcomes by exploring novel therapeutic approaches and interventions. Its state-of-the-art facilities and commitment to ethical research practices ensure that all trials are conducted with the highest standards of integrity and scientific rigor. Benha University actively contributes to the global medical community by fostering partnerships and disseminating findings that can improve patient care and inform public health policies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Benha, , Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported