Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Predictor of Intracranial Pressure

Launched by BENHA UNIVERSITY · Mar 13, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating two methods for measuring pressure inside the skull, known as intracranial pressure (ICP). Increased ICP can happen due to conditions like traumatic brain injury or bleeding in the brain, and it can be very serious. The study will include 50 patients, who will be divided into two groups: those with high ICP and those with normal levels. Researchers will use two specific tests, the Optic Nerve Sheath Diameter (ONSD) and the Optic Nerve Deformability Index (DI), to see if they can accurately predict ICP without needing invasive procedures.

To be eligible for this trial, participants must be between 18 and 65 years old and have increased ICP due to conditions like traumatic brain injury. They should also have a Glasgow Coma Scale score between 3 and 12, indicating a need for ICP monitoring. However, individuals with certain conditions, such as chronic brain issues or severe eye injuries, cannot participate. If enrolled, participants can expect to undergo non-invasive tests to measure their optic nerve and help doctors understand their intracranial pressure better. This research could lead to safer and easier ways to monitor ICP in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age 18 to 65 years
• • increased ICP (e.g., TBI, sub arachnoid hemorrhage, intracranial hemorrhage)
• • a Glasgow Coma scale=3-12 and requiring ICP monitoring via invasive methods (e.g. extra ventricular drain, lumber drain)
• Exclusion Criteria:
• • chronic hydrocephalus
• • extensive local orbit trauma
• • a pre-existing ocular disease affecting the optic nerve and/or orbital cavity
• • hyperthyroidism with exophthalmia
• • facial trauma affecting the orbits and/or eyeballs
• • optic nerve trauma
• • signs of critically raised ICP, needing urgent surgery.
• • hemodynamically unstable between ONSD acquisition and ICP measurement.
• • receiving medication that would decrease ICP between ultrasound imaging and ICP measurement, i.e. mannitol, hypertonic saline or steroids.