Metabolic Exercise Test Data Combined with Cardiac and Kidney Indexes (MECKI) Score Evolution: Identification of Cardiovascular Risk in Patients with Heart Failure

Launched by CENTRO CARDIOLOGICO MONZINO · Mar 18, 2025

Keywords

ClinConnect Summary

The MECKI trial is studying a new way to assess the risk of heart problems in patients with heart failure. Heart failure affects not just the heart but also other organs, making it important to consider various factors for a complete understanding of a patient's health. This trial aims to refine a scoring system called the MECKI score, which combines information from exercise tests and other health data to help predict the risk levels more accurately. By updating this score with new patient data and treatment approaches, the goal is to improve its effectiveness for different groups of patients.

To participate in the trial, individuals must be over 18 years old and have a history of heart failure with specific heart function measurements. Key factors include stable health conditions and having previously undergone an exercise test. Participants can expect to provide information about their health and potentially help improve how heart failure is managed in the future. Overall, this trial could lead to better risk assessments, helping doctors provide more personalized care for patients with heart failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \>18 past or present heart failure (NYHA functional class I-III, stage C of the ACC/AHA classification)
• • documentation of left ventricular systolic dysfunction (LVEF \<40%)
• • stable clinical conditions
• • previous or concomitant cardiopulmonary exercise test
• Exclusion Criteria:
• • scheduled cardiovascular treatment
• • clinical unstable condition
• • History of pulmonary embolism, significant valvular disease, pericardial disease, severe COPD, exercise-induced angina, exercise-induced ECG changes, severe brady- or tachyarrhythmias, or the presence of comorbidities that interfere with exercise performance.