PRP & PDO Threads in Treatment of Stress Incontinence

Launched by AL-AZHAR UNIVERSITY · Mar 18, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a new treatment approach for women with stress urinary incontinence (SUI), which is a condition where leaking urine occurs during activities that put pressure on the bladder, such as coughing, sneezing, or laughing. The study will involve 10 women aged between 20 and 45 years who have not found relief from other treatments and are waiting for surgery. The researchers are investigating the safety and effectiveness of a combination therapy using platelet-rich plasma (a substance derived from the patient's own blood) and PDO threads (a type of thread used in medical procedures) to help improve their condition.

To participate in this study, women must be nonpregnant and have a history of SUI that has not responded to previous treatments. However, certain health conditions could prevent someone from joining, like ongoing infections, blood disorders, or certain types of medications. If eligible, participants can expect to receive the new treatment and be monitored throughout the study to see how well it works for them. This trial is taking place at Al-Azhar University and is currently looking for volunteers to help advance understanding and treatment options for stress incontinence.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Nonpregnant Women with SUI
• • Age between 20 to 45 years
• • Patients had a history of failed conservative treatment
• • Patients were on the waiting list for surgical treatment of SUI
• Exclusion Criteria:
• • Under anti-platelet agent treatment
• • Under NSAIDs
• • Platelet dysfunction syndrome
• • Critical thrombocytopenia
• • Hypofibrionogenaemia
• • Sepsis
• • Acute and chronic infections
• • Chronic liver disease
• • Anti-coagulation therapy
• • History of malignancy
• • Pregnancy
• • history of active malignant pathology
• • mental disorders making them unable to give consent
• • genitourinary fistula
• • pelvic organs prolapse stage \>2 according to the Pelvic Organ Prolapse Quantification system, and detrusor overactivity on urodynamics.