Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy

Launched by MAYO CLINIC · Mar 13, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how the thickness of fat around the kidneys, known as Perirenal Fat Thickness (PRAT), might affect kidney function and blood pressure in people who are donating a kidney. Researchers want to see if a thicker layer of this fat can signal potential issues after kidney donation, such as changes in kidney function or increased blood pressure. They will compare different groups of living kidney donors based on their PRAT thickness and collect samples of blood, urine, and fat to study these effects.

To be eligible for this study, participants must be living kidney donors aged 18 or older, with a body mass index (BMI) either below 27 or above 30, and specific measurements of PRAT. Those interested will undergo assessments before and after their kidney donation, including lab tests and health evaluations, to help researchers gather important health information. The goal is to improve future care for kidney donors, especially regarding managing their weight and blood pressure after donation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants in this study will be restricted to living kidney transplant donors (LKDs). In order to participate, LKDs must have a BMI that is \<27 kg/m2 or ≥30 kg/m2 and a PRAT measurement score that is \<10 mm or ≥14 mm.
• Exclusion Criteria:
• • • Those who do not meet Mayo Clinic Rochester's clinical criterion for donor nephrectomy.
• • \>10% weight change between the donor evaluation and donor nephrectomy
• • Individuals who have a BMI ≥27 kg/m2 but \<30 kg/m2
• • Individuals who are pregnant or are planning to become pregnant
• • Inability to comply with study procedures or any condition that, in the opinion of the investigator, could increase the patient's risk by participating in the study or confound the outcome of the study.