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Search / Trial NCT06886087

Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy

Launched by MAYO CLINIC · Mar 13, 2025

Trial Information

Current as of April 22, 2025

Recruiting

Keywords

Healthy Volunteers Kidney Donation

ClinConnect Summary

This clinical trial is focused on understanding how the thickness of fat around the kidneys, known as Perirenal Fat Thickness (PRAT), might affect kidney function and blood pressure in people who are donating a kidney. Researchers want to see if a thicker layer of this fat can signal potential issues after kidney donation, such as changes in kidney function or increased blood pressure. They will compare different groups of living kidney donors based on their PRAT thickness and collect samples of blood, urine, and fat to study these effects.

To be eligible for this study, participants must be living kidney donors aged 18 or older, with a body mass index (BMI) either below 27 or above 30, and specific measurements of PRAT. Those interested will undergo assessments before and after their kidney donation, including lab tests and health evaluations, to help researchers gather important health information. The goal is to improve future care for kidney donors, especially regarding managing their weight and blood pressure after donation.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Participants in this study will be restricted to living kidney transplant donors (LKDs). In order to participate, LKDs must have a BMI that is \<27 kg/m2 or ≥30 kg/m2 and a PRAT measurement score that is \<10 mm or ≥14 mm.
  • Exclusion Criteria:
  • • Those who do not meet Mayo Clinic Rochester's clinical criterion for donor nephrectomy.
  • \>10% weight change between the donor evaluation and donor nephrectomy
  • Individuals who have a BMI ≥27 kg/m2 but \<30 kg/m2
  • Individuals who are pregnant or are planning to become pregnant
  • Inability to comply with study procedures or any condition that, in the opinion of the investigator, could increase the patient's risk by participating in the study or confound the outcome of the study.

Trial Officials

Aleksandra Kukla, MD

Principal Investigator

Mayo Clinic

About Mayo Clinic

Mayo Clinic is a renowned nonprofit medical practice and research institution dedicated to providing comprehensive healthcare and advancing medical knowledge through innovative research and education. With a commitment to patient-centered care, Mayo Clinic conducts numerous clinical trials aimed at exploring new therapies and improving treatment outcomes across various disciplines. Leveraging a multidisciplinary approach, the institution collaborates with leading experts and cutting-edge technology to ensure rigorous scientific standards and ethical practices in all its research endeavors. Through its trials, Mayo Clinic seeks to translate breakthroughs in science into tangible benefits for patients, fostering advancements in medicine that enhance health and quality of life.

Locations

Rochester, Minnesota, United States

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported