Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial

Launched by SAGLIK BILIMLERI UNIVERSITESI · Mar 13, 2025

Keywords

ClinConnect Summary

This study investigates the effectiveness of regenerative endodontic procedures in the treatment of necrotic and infected teeth. Traditional root canal treatment involves the complete removal of infected tissue from inside the tooth and sealing the root canal with a biocompatible filling material. However, this method does not restore the tooth's natural vitality or protective mechanisms. Additionally, it may increase tooth fragility and lead to discoloration over time.

Regenerative endodontic treatment is a biological approach that promotes the self-healing of the tooth. This method appli...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Single-rooted teeth with mature teeth with necrotic pulp requiring endodontic treatment, and a periapical lesion (Periapical Index Score (PAI) ≥3).
• • Individuals without systemic diseases, not using antibiotics, corticosteroids, antidiabetic, or antihypertensive medications, and not pregnant.
• • Patients without acute pain.
• • Patients without extraoral swelling, sinus tract, or acute apical abscess.
• • Individuals willing to participate and able to attend follow-up sessions regularly.
• Exclusion Criteria:
• • Teeth with internal or external root resorption or vertical root fractures.
• • Immature teeth.
• • Individuals outside the age range of 14-65 years.
• • Patients with complicated systemic diseases or those using antibiotics, corticosteroids, antidiabetic, or antihypertensive medications.
• • Patients with acute pain, those who have taken analgesic medication in the last 24 hours, or those who have used antibiotics within two weeks before treatment.
• • Patients who are unlikely to attend follow-up sessions.