Spectral CT Protocol Optimization for Atherosclerotic Plaque CharacterizatION

Launched by IRCCS SYNLAB SDN · Mar 14, 2025

Keywords

ClinConnect Summary

The SCORPION study is researching how to better understand a condition called atherosclerotic disease, which affects blood vessels and can lead to serious heart problems. This study aims to improve a specific type of imaging called dual-energy CT (DECT) and photon-counting CT (PCCT) to more accurately identify different types of plaque in the arteries. By refining these imaging techniques, the hope is to provide doctors with better tools for assessing patients' heart disease risks and improving their care.

To participate in the study, individuals must be over 60 years old and have had DECT imaging for heart-related issues, specifically if they have significant narrowing (more than 75%) of their coronary or carotid arteries. The study involves analyzing scans from patients to create a standardized method for plaque assessment. Participants can expect their previous imaging data to be reviewed and, if they qualify, to possibly undergo additional scans using advanced technology. Overall, this research aims to enhance how heart diseases are diagnosed and managed, ultimately leading to better outcomes for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who have undergone DECT for cardiovascular imaging (coronary and/or carotid)
• • Patients with critical stenosis (\>75% diameter, coronary or carotid artery) aged \> 60aa
• Exclusion Criteria:
• • Patients negative for critical stenosis (\<75% diameter) and/or imaging artefacts (e.g. due to movement, swallowing, or arrhythmias).
• • Patients under 60 years of age
• • Patients allergic to iodinated contrast medium (prospective phase)
• • Patients with chronic renal insufficiency (prospective phase)