Posterior Nasal Nerve Neurectomy for Treatment of Intractable Allergic Rhinitis

Launched by KAFRELSHEIKH UNIVERSITY · Mar 14, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a treatment option for people who suffer from severe allergic rhinitis, which is a condition that causes symptoms like sneezing, a runny nose, and nasal congestion. The study will compare three different methods of a procedure called posterior nasal nerve neurectomy, which aims to help patients who have not found relief from other treatments. The methods being tested include surgical removal of the nerve, a technique using radiofrequency to reduce nerve activity, and another method called surface coblation. Researchers will evaluate how well these methods work, any potential complications, and how they affect the quality of life for patients.

To be eligible for this trial, participants should be between 16 and 65 years old and have moderate to severe allergic rhinitis, confirmed by having at least three typical symptoms. However, certain individuals may not qualify, such as those with other nasal conditions, those who have used specific allergy medications recently, or those with certain health issues that could complicate surgery. If you choose to participate, you can expect to undergo one of the treatment methods, followed by assessments to monitor your recovery and improvements in your symptoms. It's important to know that this trial is not yet recruiting participants, so there will be some time before it officially begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 16 to 65 years, fit for surgery, diagnosed as moderate to severe persistent Allergic Rhinitis, as per the ARIA guidelines having 3 or more of the typical symptoms of Allergic Rhinitis including nasal discharge, repeated attacks of sneezing, nasal itching and nasal obstruction.
• Exclusion Criteria:
• • • Patients with Coexisting nasal pathologies that could influence the outcomes of the surgery like: chronic granulomatous diseases of the nose, nasal tumors, chronic sinsitis with or without nasal polyps, etc.
• • Patients who had used topical steroid nasal spray, oral or topical antihistamines, oral leukotriene antagonists, oral or tobical nasal decongestants in the last 2 weeks.
• • Immunocompromised patients, Systemic disease affecting prognosis such as diabetes mellitus, hypertension,chronic liver failure or heart failure.
• • Unwillingness for endoscopic surgery.
• • Patients younger than 18 years of age.
• • Patients who are unfit for general anesthesia.
• • Previous history of nasal surgery