Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD

Launched by UNIVERSITY HOSPITAL, CAEN · Mar 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how non-invasive ventilation (NIV) settings are used in intensive care units for patients with Chronic Obstructive Pulmonary Disease (COPD) who are experiencing acute respiratory failure. The researchers want to understand if the initial settings for NIV might affect how well patients do, including their chances of recovery or needing more invasive treatments like intubation. The trial aims to include about 976 patients from different hospitals, and will track their treatment and health outcomes over time.

To participate in this study, patients must be adults diagnosed with COPD and admitted to a medical or respiratory intensive care unit because they are having trouble breathing. They should also have specific respiratory distress that requires NIV as determined by their doctors. However, certain patients, such as pregnant women or those with other serious health issues that could complicate their treatment, will not be eligible. Participants can expect their NIV settings to be closely monitored and their health to be assessed throughout their stay in the ICU. This research hopes to improve understanding of how to best use NIV for COPD patients in critical care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult COPD Patient
• • Known or suspected COPD diagnosis as assessed by the attending physicians
• • Admitted to a medical intensive care unit (MICU), respiratory intensive care unit, or MICU
• • Hypercapnic respiratory distress
• • NIV indication determined by the physician
• • Covered by social security
• Exclusion Criteria:
• • Pregnant or breastfeeding women
• • Other obstructive diseases (asthma, bronchiectasis, cystic fibrosis, bronchiolitis, pulmonary fibrosis, restrictive thoracic syndrome) Central hypoventilation (Ondine's syndrome, iatrogenic), neurological (neuromuscular disease), osteoarticular (kyphoscoliosis), or ENT-related causes
• • Immediate need for intubation
• • Acute pulmonary edema
• • Contraindications to NIV (untreated pneumothorax, shock, cardiac arrest, uncontrolled vomiting, upper gastrointestinal bleeding, cervicofacial trauma, coma except when related to hypercapnia)
• • Patients under legal guardianship
• • Incarcerated individuals