Changes in Perioperative Blood Volume and Fluid Distribution in Patients Undergoing Primary Total Hip Replacement.

Launched by COPENHAGEN UNIVERSITY HOSPITAL, HVIDOVRE · Mar 17, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how blood volume and fluid distribution change during and after surgery for patients undergoing total hip replacement. This is important because understanding these changes can help doctors manage fluids better, which can improve recovery and reduce complications after surgery. The study will use a method called carbon monoxide rebreathing, which is a simple and non-invasive way to measure blood volume changes.

To be eligible for this study, participants need to be adults aged 18 and older who are scheduled for a total hip replacement and can understand and speak Danish. They should also be able to participate in the measurement process. However, individuals who have certain conditions, such as severe blood loss during surgery or need for a blood transfusion, or those with specific health issues that could affect the measurements, will not be included. If you join this study, you can expect to undergo the CO-rebreathing measurement before and after your surgery to help researchers better understand how blood volume changes during this procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients scheduled for an elective total hip arthoplasty (THA) in a standardized fast track setting.
• • Capable of participating in CO-rebreathing measurement
• • Age ≥ 18 years
• • Able to speak and understand Danish
• • Has provided written informed consent.
• Exclusion Criteria:
• • Intraoperative blood loss exceeding 750 mL.
• • Perioperative need for a blood transfusion.
• • Confirmed or suspected coagulopathies.
• • Factors that make CO-rebreathing measurement impossible.
• • Known orthostatic intolerance.
• • American Society of Anesthesiologists physical status (ASA) classification ≥ 4.