Comparing Effect of Opioid-sparing Versus Conventional Anesthesia on Quality of Recovery After Emergency Laparotomy

Launched by CAIRO UNIVERSITY · Mar 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two types of anesthesia for patients undergoing emergency surgery called laparotomy, which is an operation where a large cut is made in the abdomen to access the organs inside. The researchers want to see if using a lidocaine-based anesthesia, which aims to reduce the need for opioids (strong pain medications), can help patients recover better compared to traditional anesthesia that often includes opioids. They will measure recovery quality using a tool called the Quality of Recovery-15 (QoR-15) score, which asks patients about their comfort and overall recovery experience after surgery.

To be eligible for this study, participants should be adults aged 18 to 65 who are healthy enough for surgery (ASA I-III) and are set to undergo an emergency laparotomy with a midline incision. However, individuals with certain heart conditions, those who are pregnant or breastfeeding, or those with extreme body weights may not be able to participate. If you join the trial, you can expect to receive either the lidocaine-based anesthesia or the conventional type and will be monitored closely to see how well you recover after your surgery. The goal is to find out if the new approach can improve your recovery experience and reduce reliance on opioids.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (18-65 years)
• • ASA I-III undergoing emergency laparotomy with midline incision.
• Exclusion Criteria:
• • Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) and patients on beta-blockers
• • Patients on vasopressor infusion, patients with high shock index (heart rate / systolic blood pressure \>1)
• • Body mass index \<18 or \> 35 Kg/m2,
• • Pregnant or lactating women,