Rheumatoid Arthritis and Osteosarcopenia: Associated Factors

Launched by KONYA BEYHEKIM TRAINING AND RESEARCH HOSPITAL · Mar 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the connection between rheumatoid arthritis (RA) and two other conditions: osteosarcopenia (which is a combination of osteoporosis and sarcopenia, or loss of muscle mass and strength). The researchers want to see how common these conditions are in people with RA compared to healthy individuals. They will look at how sarcopenia affects the risk of osteoporosis, falling, and breaking bones. The study will involve 100 people with RA and 100 healthy participants, all of whom will be carefully chosen based on specific criteria.

To participate, individuals need to be over 50 years old and have a diagnosis of RA. They should also be able to complete the study questionnaires and tests and agree to participate by signing a consent form. During the study, participants will have their medical history taken, undergo various tests, and provide blood samples to measure levels related to RA. This information will help researchers understand how RA might influence muscle and bone health. It's important to note that certain health conditions and disabilities may exclude someone from participating in the trial.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • 1. Being diagnosed with RA according to the ACR/EULAR 2010 criteria
• • 2. Being a female or male over the age of 50
• • 3. Having the mental and physical capacity to complete the study questionnaires and tests
• • 4. Providing voluntary consent to participate in the study by signing the Informed Consent Form
• Exclusion Criteria:
• • 1. Having an acute illness/disability or significant cognitive impairment that prevents understanding and performing the required tests
• • 2. Having thyroid or parathyroid disease, uncontrolled diabetes, Cushing's syndrome, anemia.
• • 3. History of malignancy
• • 4. Severe cardiovascular disease, enal failure, advanced-stage COPD, decompensated liver disease
• • 5. History of gastrointestinal (GIS) surgery
• • 7-Having another coexisting autoimmune/inflammatory rheumatic disease (e.g., SLE, Ankylosing Spondylitis, etc.), psoriatic arthritis, vasculitis, familial Mediterranean fever...)
• • 8-Having severe/symptomatic hand osteoarthritis and/or deformities
• • 9-Severe/symptomatic osteoarthritis in the knee, lumbar, hip, or ankle region
• • 10-Having Carpal Tunnel Syndrome, De Quervain, lateral epicondylitis, cubital tunnel syndrome or a history of traumatic hand injury
• • 11-Having a significant neurological disease, stroke, MS, myopathy, Parkinson's disease, radiculopathy/polyneuropathy/brachial plexopathy or others nerve root compressions
• • 12-History of surgical intervention on the upper and lower extremities or spine
• • 13-Having severe kyphosis or scoliosis
• • 14-Having any others disease causing balance disorders (neurological, orthopedic, metabolic, etc.)
• • 15-Having a major/significant psychiatric disorder (based on the medical history, and hospital records)
• • 16-Current use of androgens or estrogens
• • 17-Having prostheses, being fully dependent, or immobilized