Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS

Launched by ATTIKON HOSPITAL · Mar 20, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain markers related to heart and blood vessel health are affected in women with Polycystic Ovary Syndrome (PCOS) during a glucose tolerance test, which checks how the body handles sugar. The researchers want to understand if these markers change after treatments over six and twelve months. Essentially, they are looking into how PCOS might impact heart health and how different treatments might help improve that.

To participate in this study, women must be over 16 years old and have a diagnosis of PCOS based on specific criteria. They should not have received any treatment for PCOS in the last six months. Women with other medical conditions that could mimic PCOS, those who are currently pregnant or breastfeeding, or those with certain other health issues like diabetes are not eligible to join. Participants can expect to undergo tests and monitoring related to their heart and blood vessel health, helping researchers learn more about how to manage PCOS effectively.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \> 16 years old
• 2. Diagonis of PCOS according to Rotterdam criteria: presence of two of the three of the following:
• • Clinical or biochemical hyperandrogenism
• • Anovulation or oligo-ovulation
• • Polycystic ovarian morphology (PCOM)
• • 3. Absence of treatment for PCOS the last six months
• • 4. Patients who have the ability to understand and sign the consent form.
• Exclusion Criteria:
• • 1. Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone \[17-OHP\]), Cushing syndrome, acromegaly
• • 2. Treatment with contraceptive or metformin
• • 3. Type 2 diabetes mellitus
• • 4. Treatment for diabetes
• • 5. Pregnancy
• • 6. Lactation
• • 7. Malignancy