Fecal Calprotectin in Patients Infected with Intestinal Protozoan Infections

Launched by SOHAG UNIVERSITY · Mar 17, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to understand how a substance called fecal calprotectin, found in stool samples, relates to certain intestinal infections caused by two types of protozoa: Blastocystis hominis and Entamoeba histolytica. Researchers want to see if levels of fecal calprotectin can help identify inflammation in the intestines of patients who have these infections compared to those who do not have them. The trial will collect a total of 120 stool samples from three groups: patients with gastrointestinal issues who have these infections, patients with gastrointestinal issues who do not have any protozoal infections, and healthy volunteers without any gastrointestinal problems.

To be eligible for this trial, participants should be experiencing gastrointestinal symptoms and either be infected with one of the two protozoa or be free of any infections. It's important that participants have not taken any antiparasitic or antibiotic medications in the two weeks before providing their stool samples. This study is not yet recruiting participants, but if you fit the criteria, you could help researchers gain valuable insights into how fecal calprotectin levels relate to these infections, which could lead to better diagnosis and treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 120 fecal samples will be collected as the following:
• • 40 samples from patients complaining of gastrointestinal manifestations and only infected with B.hominis and E.histolytica.
• • 40 samples from patients complaining of gastrointestinal manifestations without any protozoal infection.
• • 40 healthy control cross-matched volunteers (without gastrointestinal manifestations, or intestinal parasites).
• Exclusion Criteria:
• • persons received antiparasitic drugs or antibiotic 2 weeks before sample collection Patients with mixed intestinal protozoa Patients with intestinal protozoa rather than Entamoeba histolytica and Blastocystis