Circadian Rhythms in Human Adipose

Launched by MAYO CLINIC · Mar 21, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to learn more about how our body's internal clock, known as circadian rhythms, affects fat tissue, particularly in people with obesity. Researchers want to see how these rhythms change when people eat continuously or follow regular eating patterns. By studying this, they hope to find better ways to understand and manage obesity.

The study is open to individuals aged 65 to 88 years, regardless of gender. To participate, you should have a body mass index (BMI) between 20-25 or 30-37 and, if you have obesity, your waist should be larger than your hips. Participants should be generally sedentary and not pregnant or breastfeeding. You will not be eligible if you have certain medical conditions, sleep issues, or if you smoke. If you join the study, you can expect to follow specific instructions and provide written consent to participate. This research could help uncover important information about how our bodies process fat and the impact of our eating habits.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI 20-25 kg/m2 or 30-37 kg/m2
• • For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
• • sedentary
• • females: non pregnant or breastfeeding
• • ability to provide written informed consent and follow study instructions
• Exclusion Criteria:
• • History of mediations that impact adipocyte/lipid metabolism
• • smoking
• • insomnia
• • sleep apnea
• • sleep medication use
• • employment in night or shift work
• • extreme chronotypes
• • Allergy to lidocaine