ClinConnect ClinConnect Logo
Search / Trial NCT06892106

Gut Dysbiosis in Spinal Cord Injury Rehabilitation

Launched by CENTRO ACADEMICO CLÍNICO EGAS MONIZ HEALTH ALLIANCE · Mar 18, 2025

Trial Information

Current as of April 30, 2025

Completed

Keywords

Spinal Cord Injury Rehabilitation Gut Microbiota Immune System Gut Immune Cns Axis

ClinConnect Summary

Background:

Spinal cord injury (SCI) is a devastating condition with no effective cure. Gut dysbiosis and chronic immune dysfunction are common complications that may hinder recovery. This study aims to investigate the role of gut microbiota and related immune biomarkers and metabolites in the functional recovery of SCI patients during the subacute phase. This study hypothesizes that alterations in the gut microbiota and associated immune responses are critical factors influencing recovery trajectories in patients during the subacute phase of SCI.

Therefore, we aim to investigate the intr...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adults (≥18 years) with traumatic spinal cord injury.
  • Injury occurred less than 6 months ago (subacute phase).
  • Any neurological level of injury (AIS A-D).
  • Exclusion Criteria:
  • Use of probiotics or immunomodulatory drugs in the last month.
  • Major gastrointestinal surgery in the last 5 years.
  • Active gastrointestinal diseases or other CNS diseases.

About Centro Academico Clínico Egas Moniz Health Alliance

The Centro Académico Clínico Egas Moniz Health Alliance is a distinguished clinical trial sponsor dedicated to advancing medical research and improving patient outcomes through innovative studies. Located in Portugal, this alliance combines the expertise of academic institutions, healthcare professionals, and industry partners to conduct rigorous clinical trials across various therapeutic areas. With a focus on high ethical standards and patient-centered approaches, the organization aims to contribute significantly to the development of new therapies and enhance the overall quality of healthcare through evidence-based solutions.

Locations

Gaia, Porto, Portugal

Patients applied

0 patients applied

Trial Officials

Maria Ribeiro da Cunha, PhD

Principal Investigator

Centro de Reabilitação do Norte (CRN) / Unidade Local de Saúde Gaia e Espinho (ULSGE))

Sandra Vieira

Study Director

Institute of Biomedicine - Aveiro University (iBiMED-UA)

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported