Gut Dysbiosis in Spinal Cord Injury Rehabilitation
Launched by CENTRO ACADEMICO CLÍNICO EGAS MONIZ HEALTH ALLIANCE · Mar 18, 2025
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
Background:
Spinal cord injury (SCI) is a devastating condition with no effective cure. Gut dysbiosis and chronic immune dysfunction are common complications that may hinder recovery. This study aims to investigate the role of gut microbiota and related immune biomarkers and metabolites in the functional recovery of SCI patients during the subacute phase. This study hypothesizes that alterations in the gut microbiota and associated immune responses are critical factors influencing recovery trajectories in patients during the subacute phase of SCI.
Therefore, we aim to investigate the intr...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adults (≥18 years) with traumatic spinal cord injury.
- • Injury occurred less than 6 months ago (subacute phase).
- • Any neurological level of injury (AIS A-D).
- Exclusion Criteria:
- • Use of probiotics or immunomodulatory drugs in the last month.
- • Major gastrointestinal surgery in the last 5 years.
- • Active gastrointestinal diseases or other CNS diseases.
About Centro Academico Clínico Egas Moniz Health Alliance
The Centro Académico Clínico Egas Moniz Health Alliance is a distinguished clinical trial sponsor dedicated to advancing medical research and improving patient outcomes through innovative studies. Located in Portugal, this alliance combines the expertise of academic institutions, healthcare professionals, and industry partners to conduct rigorous clinical trials across various therapeutic areas. With a focus on high ethical standards and patient-centered approaches, the organization aims to contribute significantly to the development of new therapies and enhance the overall quality of healthcare through evidence-based solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Gaia, Porto, Portugal
Patients applied
Trial Officials
Maria Ribeiro da Cunha, PhD
Principal Investigator
Centro de Reabilitação do Norte (CRN) / Unidade Local de Saúde Gaia e Espinho (ULSGE))
Sandra Vieira
Study Director
Institute of Biomedicine - Aveiro University (iBiMED-UA)
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported