ClinConnect ClinConnect Logo
Search / Trial NCT06892899

Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study

Launched by MAY ARNA RISBERG · Mar 21, 2025

Trial Information

Current as of April 29, 2025

Enrolling by invitation

Keywords

Knee Injury Anterior Cruciate Ligament Injury Knee Joint Loading Quadriceps Muscle Strength Quadriceps Muscle Function Post Traumatic Knee Osteoarthritis Risk Factors Prevention

ClinConnect Summary

The main risk factors for knee OA disease are well-known: joint injuries and obesity. For those with ACL injury, systematic reviews have reported between 4 to 6 times increased risk of developing OA after ACL injury (PTOA). The following risk factors have been identified for PTOA in a recent systematic review by our OPTIKNEE group: ACL injury with concomitant injuries (meniscus and cartilage injuries), re-injuries after ACL injury, long-lasting quadriceps dysfunction, and inflammation after joint injury.

A better understanding of mechanisms to stratify the patients into different subgroups...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Unilateral ACL injury and ACLR (≤ one year between injury and surgery)
  • Surgery performed using the BPTB or hamstring grafts
  • Age between 16 and 40 years
  • Isolated ACL or with concomitant meniscal injury/cartilage injuries at surgery
  • Location (living) in the Oslo or Viken areas (due to the need for testing performed at the Norwegian School of Sport Sciences and Oslo University Hospital)
  • Healthy, uninjured contralateral knee
  • Exclusion Criteria:
  • Above 40 years and below 16 years of age
  • Previous ACL injury (re-rupture of graft or an ACL injury more than one year between injury and surgery)
  • MCL/LCL grade 3 injuries
  • Other lower extremity injuries less than one year before inclusion, or previous inflammatory arthropathy or systemic infection or inflammation
  • Participants with bilateral ACL injuries

About May Arna Risberg

May Arna Risberg is a dedicated clinical trial sponsor focused on advancing medical research and improving patient outcomes through innovative therapeutic solutions. With a commitment to rigorous scientific standards and ethical practices, the organization actively collaborates with healthcare professionals and research institutions to design and conduct clinical trials across various therapeutic areas. By fostering a culture of transparency and collaboration, May Arna Risberg aims to accelerate the development of new treatments, ultimately enhancing the quality of care for patients worldwide.

Locations

Oslo, , Norway

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported