Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients with Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula

Launched by FORO INTERNACIONAL EN CUIDADO CRÍTICO · Mar 21, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to study how well the diaphragm, a key muscle for breathing, works in patients who are experiencing serious breathing difficulties. The researchers want to see how diaphragm function changes when patients receive different types of breathing support, such as high-flow oxygen or non-invasive mechanical ventilation. By using ultrasound, a safe imaging technique that uses sound waves to create pictures of the diaphragm, the study will help doctors understand how effective these treatments are in helping patients breathe better.

To participate in this study, individuals must be at least 18 years old and have acute respiratory failure, which means they are not getting enough oxygen or are having trouble getting rid of carbon dioxide. However, certain conditions, such as having a tracheostomy (a surgical opening in the neck for breathing) or severe obesity, would exclude someone from taking part. If eligible, participants can expect to undergo a simple ultrasound of their diaphragm as part of their routine care while receiving breathing support. This study aims to gather important information that could improve treatment for people with breathing disorders in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Hypoxemic respiratory failure (SpO2 \< 88% - PaO2 \< 60 mmHg) or hypercapnic (PaCO2 \> 40)
• • Need for NIMV and/or HFNC.
• Exclusion Criteria:
• • Neuromuscular disease
• • Pregnancy
• • Tracheostomy
• • Rib fractures
• • Cervical injuries
• • Diaphragmatic paralysis
• • Diaphragmatic malformations
• • Hemodynamic instability
• • Morbid obesity (BMI \> 35)
• • Use of sedation and neuromuscular relaxants
• • Pneumothorax or pneumomediastinum
• • Poor acoustic window
• • Critically ill patients with a prognosis of less than 24 hours of life Patients receiving palliative interventions.