The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers

Launched by MEDICAL UNIVERSITY OF GRAZ · Mar 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a natural supplement called Griffonia simplicifolia, which contains a compound known as 5-hydroxytryptophan (5-HTP). This compound may help increase serotonin levels in the brain, which can influence mood and possibly help with pain management. The researchers want to understand how 5-HTP affects different types of pain and the body's response to it, especially in people who experience chronic pain. They will do this by using a method that safely induces short-term pain in healthy volunteers and measuring how well 5-HTP works in reducing that pain.

To participate in this study, you need to be aged between 18 and 65 years and generally healthy, without chronic pain or certain medical conditions. This means if you are pregnant, breastfeeding, or have specific health issues like liver or kidney problems, you won’t be eligible. Participants will undergo tests involving heat application to measure pain responses, and they will also answer questionnaires about mood, sleep, and overall well-being. This trial is currently recruiting, and your involvement could help improve understanding of how 5-HTP might be used for pain relief in the future.

Gender

ALL

Eligibility criteria

• Exclusion Criteria:
• • pregnancy or breastfeeding.
• • renal or hepatic insufficiency
• • neurological/dermatological/cardiovascular diseases
• • chronic pain and/or use of analgesics
• • intake of antidepressants
• • intake of MAO inhibitors
• • intake of sleep medication
• • intake of St. John's wort
• • allergy to Griffonia simplicifolia