Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain
Launched by UNIVERSITY OF JORDAN · Mar 23, 2025
Trial Information
Current as of July 01, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at a new way to help reduce pain after root canal treatment for patients with specific dental issues, including serious tooth infections or pain. The researchers want to find out if applying a medication called dexamethasone directly into the area around the tooth can help lessen the pain after the procedure compared to a placebo, which is like a dummy treatment without the active medication. The study will involve adults aged 18 to 70 who have been diagnosed with a certain type of tooth problem, but it won't include those with more severe health issues or specific conditions that could interfere with the results.
If you or someone you know is considering participating, it’s important to know that the study is not yet recruiting participants. Eligible individuals will be healthy adults with specific types of dental pain, but not those who have had previous treatments on the same tooth or other complicating factors. Participants can expect to receive either dexamethasone or a placebo during their root canal treatment, and the goal is to see if the medication can help manage pain more effectively. This research could lead to better pain management options for patients undergoing similar dental procedures in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • A diagnosis of irreversible pulpits with symptomatic apical periodontitis
- • Adult patients (aged 18 - 70)
- • Healthy patients or those with a well-controlled disease (ASA I \& II)
- Exclusion Criteria:
- • A diagnosis of necrotic pulp, or normal apical tissues
- • Patients with a severe systemic disease (ASA III or higher)
- • Patients who received analgesics12 hours before presentation
- • Previously treated/initiated Endodontics treatment on the same tooth
- • Unopposed teeth
- • Third molar teeth
- • Non-restorable teeth
- • Periodontally compromised teeth
- • Pregnant or lactating patients
About University Of Jordan
The University of Jordan, a leading institution in higher education and research in the region, is dedicated to advancing medical knowledge and improving healthcare outcomes through innovative clinical trials. With a commitment to ethical research practices and collaboration with various stakeholders, the University of Jordan aims to contribute significantly to the field of medicine by exploring new treatments and interventions. Its robust infrastructure and expertise in diverse health-related disciplines enable the university to conduct high-quality studies that address pressing health challenges, ultimately enhancing patient care and fostering scientific discovery.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported