Comparing Unilateral and Bilateral Proximal GONPRF in Migraine Treatment

Launched by ANKARA CITY HOSPITAL BILKENT · Mar 24, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to treat migraines using a technique called Greater Occipital Nerve Pulsed Radiofrequency (GON-PRF). The researchers want to find out if treating one side of the head (unilateral) is as effective as treating both sides (bilateral) when it comes to reducing migraine symptoms. The treatment will be guided by ultrasound, which helps doctors see exactly where to work. The study also aims to understand how each method affects daily life and whether there are any side effects or complications.

To participate in this study, you need to be between 18 and 65 years old and have been diagnosed with either episodic (having five or more migraine attacks a month) or chronic migraines. It's important that you haven't found relief from migraine medications and that you haven’t changed your medication in the last three months. You also need to be in good health overall, with no bleeding disorders or active infections. If you decide to join, you can expect to receive treatment and follow-up care to monitor your progress and any side effects. This research could help improve migraine treatment options in the future!

Gender

ALL

Eligibility criteria

• • Inclusion Criteria:Volunteers who are followed up at the Algology polyclinic of Ankara Bilkent City Hospital, between the ages of 18-65, who meet the diagnosis criteria for episodic (≥5 attacks/month) or chronic migraine according to ICHD-3 criteria, who do not benefit sufficiently from the migraine prevention medications used, who are not currently using migraine prevention medications or who have not changed their medication and/or dosage in the last 3 months, who do not have bleeding-clotting disorders and active infection in laboratory tests, who are not pregnant or suspected of being pregnant, who do not have a history of craniocervical surgery that may disrupt the anatomical structure in the intervention area, who can understand and approve the treatment and the informed consent form and who can comply with the treatment will be included in this study. Exclusion criteria for files/records/materials to be included in the study: Patients with a history of primary headache other than migraine according to ICHD-3 criteria, \<5 attacks per month, comorbid diseases that may cause headaches (such as uncontrolled hypertension, intracranial lesions), and those who have received interventional treatment, botulinum toxin injection and/or non-pharmacological treatment (acupuncture, physical therapy, ozone, cognitive behavioral therapy, etc.) for migraine within 3 months prior to GON-PRF treatment will not be included in the study.
• • -
• • Exclusion Criteria:The voluntary participants' request to withdraw for any reason at any stage of the study, the volunteer/legal representative's withdrawal of consent to participate in the study, failure to attend follow-up, and the emergence of any of the following criteria for not being included in the study.
• • -