ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation

Launched by UNIVERSITY OF MINNESOTA · Mar 18, 2025

Keywords

ClinConnect Summary

The ADHERE-LPV trial is studying how to improve the way hospitals use a specific type of ventilation called lung-protective ventilation (LPV) for patients who need help breathing. This trial will take place in 10 different hospitals and will compare outcomes for patients before and after a new system is introduced. Some hospitals will use a new strategy that changes the way ventilator settings are automatically set in their electronic health records (EHR). This approach is designed to help doctors follow LPV guidelines better, which can lead to improved patient care. After a 9-month period, the strategy will be shared with all participating hospitals.

To be eligible for this study, participants need to be 18 years or older and require mechanical ventilation, which is a machine that helps patients breathe. However, patients who have opted out of research, have certain medical conditions, or have specific documentation related to their care may not be included. Because this is a cluster trial, hospitals will be grouped by size, ensuring that both large and small hospitals are involved, which helps researchers understand how well the strategy works in different settings. If you or a family member are eligible, you can expect to contribute to important research that aims to improve breathing support for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 and over
• • Requires mechanical ventilation
• Exclusion Criteria:
• • The patient opted out of research
• • The mode ordered does not require a set tidal volume
• • Requires ECMO prior to ICU admission
• • Data during the use of ECMO
• • Hospitalization was for an elective surgery
• • The duration of mechanical ventilation was less than 12 hours (these are not the patients that would benefit from LPV)
• • Admission code documentation of Do Not Intubate. While rare, in situations where a patient was intubated but whose preferences are contradictory to the current care, mechanical ventilation is managed differently while undergoing goals of care conversations.
• • Height was documented as less than 4 feet given the PBW formula was not validated below this height.