Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.

Launched by BEIJING TSINGHUA CHANG GUNG HOSPITAL · Mar 25, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how two surgical techniques, called Pringle occlusion and portal vein occlusion, may affect heart injury in patients who are undergoing major non-cardiac surgeries, especially in the liver area. The goal is to understand how these techniques might lead to heart issues after surgery and to identify factors that can help doctors recognize and prevent these problems early on. Researchers will gather information from patients who are scheduled for this type of surgery to see how often heart injuries occur with each technique.

To participate in this study, individuals need to be at least 65 years old, or at least 45 years old with certain heart risk factors, and must be undergoing planned major liver surgery. Participants will be asked to provide their consent to join the study. Those with emergency surgeries, serious heart conditions, or certain other health problems will not be eligible. Throughout the trial, participants can expect regular follow-ups to monitor their health after the surgery. This research aims to improve patient care and outcomes after major surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 65 years, or ≥ 45 years with cardiovascular risk factors (especially known cardiovascular disease).
• • Undergoing elective major hepatopancreatobiliary surgery under general anesthesia.
• • ASA physical status II-III.
• • Provide written informed consent to participate in the study (applicable to the prospective cohort).
• Exclusion Criteria:
• • Emergency surgery
• • Preoperative diagnosis of myocardial infarction or unstable angina
• • Severe hepatic insufficiency (Child-Pugh class C)
• • Concomitant severe organ dysfunction (e.g., renal failure, respiratory failure)
• • Concomitant active infectious disease