Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis
Launched by ASSIUT UNIVERSITY · Mar 24, 2025
Trial Information
Current as of April 22, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Autoimmune hepatitis (AIH) is a rare and chronic inflammatory disease of the liver of unknown etiology characterized by loss of immune tolerance against liver antigens leading to progressive destruction of hepatic parenchyma and if untreated leads to end-stage liver disease.
It affects all ages with a peak incidence in pediatric age, where it is referred to as Juvenile Autoimmune Hepatitis (JAIH).JAIH is a long-term condition that varies in intensity over time. It occurs more frequently in females and is marked by increased levels of serum gamma globulins, the presence of autoantibodies in...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients aged between one day and 18 years (children)
- • patients diagnosed clinically and physically with juvenile autoimmune hepatitis including seronegative autoimmune hepatitis cases
- Exclusion Criteria:
- • 1. Cases with inadequate tissue in the paraffin block
- • 2. Children with viral hepatitis
- • 3. patients above the age of 18 years old
Trial Officials
Howadya Ismail Hassan El Sayed, PhD
Study Director
Assiut University
Moemen Mostafa Ahmed Hafez, PhD
Study Director
Assiut University
About Assiut University
Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Related Blog Entries
View all
